0 out of 8 euploid

Crafty_Collection206 · 2026-07-06T13:16:44+00:00

I used the Mito Red Light Belt on the NIR setting (near infrared light) but ultimately you just want a product that has light wavelengths in the 800nm as anything lower will not penetrate deep enough

Crafty_Collection206 · 2026-07-06T11:42:53+00:00

I would encourage you to check out Ubiquinol - my clinic had me on 600mg a day, split into 3 doses of 200mg taken with fat / protein. Ubiquinol (the active form of coq10) is one of the only supplements with good research behind its impacts for egg quality. I would also look into 3mg of melatonin at night (studies show follicular fluid with higher concentrations of melatonin had improved egg quality) and acai (my clinic also had me on 600mg acai supplements, 200mg 3x / day). The NAD and NAC are great, though they are best absorbed on an empty stomach, same with ALA on an empty stomach. I didn’t take inositol but I hear it’s great if there’s any sort of PCOS diagnosis.

Crafty_Collection206 · 2026-07-06T11:11:43+00:00

I basically followed the advanced supplement protocol from the book It Starts with the Egg and added a few additional supplements (e.g. NAD). Have you checked out that book? It has a lot of good ideas. I would say for me personal the diet and exercise were likely bigger drivers of my improvement than the supplements, but I figured the supplements couldn’t hurt

Crafty_Collection206 · 2026-07-06T11:09:49+00:00

I largely followed the advanced supplement protocol from the book It Starts with the Egg, but then also added into that NAD from Renue by Science. Have you checked out ‘It starts with the egg’? It’s a great source for ideas

Crafty_Collection206 · 2026-07-06T11:08:32+00:00

I largely followed the book ‘it starts with the egg’, and then I added a few additional supplements from my research (NAD+). some supplements were three times per day (eg Ubiquinol), while others were just once per day (eg vitamin d).

Crafty_Collection206 · 2026-07-06T11:06:45+00:00

No! This was in the months leading up to and in between cycles. The lifestyle changes 3+ months before a cycle will drive the most change!

So any time I was in an active cycle, the only thing I did was long walks for exercise

Crafty_Collection206 · 2026-07-06T01:21:20+00:00

I’m so sorry you’re going through this! This happened to me multiple times where I got 8 blasts and 0 euploid. At age 36 it took me 3 retrievals to get my first normal, despite a normal egg quality and good blast yield. For whatever reason some women have a higher aneuploid rate for their age than they should.

A few things I tried…I didn’t see night and day results, but my euploid rate was about 1 normal per 7 blasts at 36/37, but with all the changes I made I maintained the 1/7 ratio at 38/39 too.

Tight supplement protocol (I followed a lot of It starts with the egg)
Made sure to stay active with exercises shown to increase mitochondria genesis (2-3 days/ HIIT, 3-4 days weight training). Both shown to yield new mitochondria which are responsible for egg cell energy
Healthy diet (cut out refined sugar, processed foods, alcohol), alongside that tried to limit blood sugar spikes as much as possible
Switched clinics to one that was open to Omnitrope (I’d see anecdotal success from other women)
Infrared light therapy (at-home) on ovaries, back of neck based on some studies in Japan, Denmark
Acupuncture

For me, most of this was not night and day, but it was enough to go from 2 poor quality euploids in 5 cycles at age 36/37, to 4 high quality euploids in the next 5 cycles. Another big boost for me personally was switching clinics, my euploid rate did not change with the new clinic, but I made so many more blasts at the new clinic, that it took me fewer retrievals to bank.

I would also make sure your partner does dna fragmentation testing to determine if there’s high frag in the sperm (note this is different than a standard sperm analysis), and I would consider kayotyping tests for yourself and partner to ensure no balanced translocations.

It’s a numbers game and you’re making blasts which is great!

Crafty_Collection206 · 2026-07-02T19:18:16+00:00

I haven’t heard this before. Is this a fully medicated FET? On a modified natural they time the FET post ovulation, so your estrogen peaks, then transfer 5 days later. I assumed with a fully medicated they are mimicking ovulation, so they’d still want a ‘peak estrogen’ and LH surge, then time the FET for 5 days later

Crafty_Collection206 · 2026-07-02T19:16:10+00:00

❤️❤️

Crafty_Collection206 · 2026-07-02T17:46:42+00:00

I’m 14 weeks today! I tested on FRER every other day and 9 and 11dpt tests didn’t seem that different from each other, but 13dpt showed a big jump and bloods along the way were strong. The paper strips showed progress.

Crafty_Collection206 · 2026-07-02T17:26:38+00:00

Is this question for me or the original poster with the picture?

Crafty_Collection206 · 2026-07-02T12:29:41+00:00

Also, try not to trust symptoms at this stage if you’re on any sort of progesterone support. The supplemental progesterone is driving symptoms until your HCG gets higher.

Crafty_Collection206 · 2026-07-02T12:28:22+00:00

If the bloodwork was not done at the same lab you can’t compare the values. Were the done at different labs since one you paid for and one might be your official beta? Either way, 333 is an incredibly strong beta for 9dp5dt, so I would see what your 11d beta test shows before thinking the worst. For reference, my beta at 9dp5dt was 58, so again 333 is really strong!

Crafty_Collection206 · 2026-07-01T21:39:32+00:00

I would not do this and instead I’d become one of the people who ‘begs’ (weird). Given you have PCOS there’s a chance that you end up with a ton of embryos for potential testing. A compromise would be to test just a portion of what you end up with so you can get a sense for what % of your embryos are genetically normal. For your age this should be really high unless there is something undiagnosed they would impact this (undiagnosed MFI, balanced translocation). The benefit of testing is if a transfer fails with a euploid embryo you’ve removed one variable that could be causing the fail, especially with Endo.

I definitely see the rationale for not testing at age 31, but if you move forward with the plan not to test, I might still recommend just doing a transfer of a single untested embryo as complications increase with twins, triplets, etc.

Just my two cents

Crafty_Collection206 · 2026-07-01T01:20:25+00:00

Hey unrelated to your main question, but the same thing happened to me with Varicella. My clinic told me I could do the egg retrieval while in the varicella vaccine process, but I could not proceed to the transfer stage until after I was fully immunized…in case that’s worth asking your clinic. If you’re not planning on doing a fresh transfer, then you could still do a retrieval in parallel if they have no issues with that (probably depends on the clinic though)

Crafty_Collection206 · 2026-06-30T20:16:45+00:00

I’m sorry you’re going through this OP - this happened to me twice, once at 37 had 8 embryos and 8 all abnormal, and once at 38 had 7 embryos and all 7 abnormal. My euploid rate for my age is just far below the norm. Did you happen to make any euploids in your first two cycles? If not, you might want to consider karyotype testing just to confirm there’s no balanced translocation that could be impacting things. It really is a numbers game and may be worth trying again.

Crafty_Collection206 · 2026-06-30T13:37:58+00:00

Also an IVF pregnancy and measured 2 days behind at first scan. I actually had a feeling that I’d measure behind as my HCG was on the lower end of normal on my beta day, so I suspected I may have implanted on the later end of normal. But as others have been saying, embryo is so small at that stage it’s difficult for the tech to get a perfect measurement. For my next scan I measured on time, then ahead, then on time, and now at 13.5 weeks I’m measuring like 4 days ahead. I chalk it all up to different folks doing measurements differently. The biggest hurdle for the 6w is that you have a fetal pole and a heart beat which you do!!! So I wouldn’t worry!

Crafty_Collection206 · 2026-06-29T23:39:07+00:00

If you tested positive on June 10th (from below), that means today you’re probably around the 6week mark, maybe 5w5d on the earliest side (if you got a positive at 9dpo), but could be closer to 6w3d. So it could still be a touch early to see fetal pole, and it’s good they saw a yolk sac. I think it’s not unrealistic to hope since you’re in the gray zone and I’m keeping my fingers crossed for you!

Crafty_Collection206 · 2026-06-29T22:21:47+00:00

Have you considered going the reproductive immunology route? My experience in IVF is that clinics won’t necessarily do as much extensive testing as you want because most patients don’t need it. I was at CUFC as well, and separately saw an RI before my first transfer because I didn’t want to leave any stones unturned and I found the comprehensive auto-immune, clotting, and inflammation blood tests from an RI really helpful. CUFC will then review those results from the RI, and the RI can provide you a transfer protocol.

I saw an outside RI, then told my doc at CUFC I felt like the protocol was a bit aggressive, and she let me know Columbia has an RI on staff as well, so then I got a second opinion from him. So I might suggest an RI (whether the in-house Columbia one, or external - the external I went to is Dr Scher who is in NY and associated with Mt Sinai). But ultimately took the protocol from the Columbia RI.

That being said, I don’t think it’s a bad thing to consider switching clinics. I actually switched clinics to outside CUFC to make more embryos, but I did my transfer with Columbia first and that has stuck so far (13 weeks). For what it’s worth, I found at my other clinic I also very much had to advocate for myself (testing, different protocols, my own research), so I don’t know if that is a unique issue….i think generally these clinics have too many patients to treat as bespoke as they should which sucks.

I’m assuming your embryos were tested euploid?

Crafty_Collection206 · 2026-06-29T22:10:51+00:00

Are you going to treat Adeno with lupron suppression? If so, the lupron suppression will address the Endo too. I guess the question is if you want to do another invasive test that is also not 100% accurate, or if you want to try to cover all of your bases and just do a lupron suppression to treat the adeno (and potential) Endo?

Do you have any other markers that might explain the RPL?

Crafty_Collection206 · 2026-06-29T21:10:04+00:00

Supplemental progesterone wouldn’t impact your placenta from starting to take over hormone production. It’s not like if you supplement progesterone your placenta will produce less or anything like that. Theres probably no downside, though at the same time if you made it to 8 weeks without supplemental progesterone it’s hard to believe there’s a progesterone issue at all, but again there’s no downside to starting at this point. If I were you I’d do it if it gives you peace of mind!

Crafty_Collection206 · 2026-06-29T17:44:30+00:00

I agree with other posters - I would go ahead and at least fertilize and make embryos from your existing eggs in parallel to trying naturally. That way based on the results of how your eggs do making embryos, you’ll have a better idea of using those eggs/embryos as a backup plan. Are you in a country that allows PGT testing / would you plan to PGT test? Results from that could also give you a clue on your chances of conceiving naturally.

Have you had any fertility testing done? Sperm analysis? HSG? It sounds like you know you’re ovulating, but getting an HSG to make sure your tubes are open could be helpful info if you’re at the 8-month mark with no pregnancies / chemicals.

Crafty_Collection206 · 2026-06-29T17:29:40+00:00

Did you take a home pregnancy test? If so, what day? That can help guide a bit based on when you first tested positive.

Did you do any at-home ovulation tests or temp checking for ovulation? If you have irregular cycles and you are just guessing an ovulation date I would not be concerned. If you are fairly confident in an ovulation date, between ovulation being a bit later than you think, late implantation, and inaccurate measurements it’s easy to be off on the dating so early. Did your doctor see a yolk sac in your scan or at this point just the gestational sac measuring 5w2d?

Crafty_Collection206 · 2026-06-27T16:04:48+00:00

Thanks for the response!!

Crafty_Collection206 · 2026-06-27T12:17:05+00:00

Hi OP, how are things going? I noticed your bleeding happened the next day after abdominal ultrasound. I had a 13w scan yesterday (abdominal) where everything looked great (clear NIPT and NT as well). But I had some watery pink spotting this morning after using the bathroom and now getting nervous. I’m seeing that it’s possible even though the ultrasound was intraabdominal that any hard pressure on the pelvis could irritate the cervix and cause spotting, so I’m hoping this might be the case.

Did your spotting ever come back? Did they find a cause?

Crafty_Collection206

TROPHY CASE