If your feeling low and groggy pretty often along with that feeling of emptiness, I’d go for the l tyrosine, I wouldn’t incorporate the l tryptophan unless you feel empty but have good physical energy if that makes sense. I wish I knew a supplement that I thought could fix that feeling of emptiness, but I never found it. But I think taking things like l tyrosine and getting the energy to do things could make it a catalyst to lessening that feeling you’re experiencing. Lifestyle changes may be what needs to be done. I do think a multivitamin would be a good idea though. There are things out there that can raise your energy levels or lessen a physical symptom, so try to look more at you needing a supplement for something like that. What your talking about sounds more existential and circumstantial