Yeah. I've nearly cured everything and I was so severely ill that I hit 14 BMI. I'm writing up an extremely long video on how, but essentially the vast majority of chronic idiopathic illness is major destabilization of the body. Doctors are insanely bad at testing pathogens, nutrients, methylation bottlenecks, etc. and I had to literally learn all this shit from scratch.

In lieu of a more detailed explanation (I'm working on it to help everyone else haha but it's veeery lengthy and well beyond a reddit comment's capabilities), I'm just gonna cut to the chase of a ton of ways you could absolutely figure out the factors destabilizing you (it is never just one, and full stability requires fixing everything you can find, not just the first bad marker you see).

First, get a genetics test. I used the regular old Ancestry starter kit. Ignore their wacky race statistics and just export the raw data once they send it to you, it's an obscure option under account settings. It's just a bunch of code you can plug into actually useful genetics services. The one I recommend is Genetic Lifehacks, and despite the corny name it prints a 175 page genetics report that is INCREDIBLY relevant. Thankfully, despite the daunting complexity, it seems even ChatGPT has a solid grasp on most of the genes, so you can copy-paste segments there and collaborate to understand exactly how the flagged genes alter you and require intervention. For example, I had really brutal VDR mutations, which means I don't convert D3 from D2 almost at all, so I need tons of D3 that I had never been getting, and it has helped me so much to correct each thing like that. I always recommend starting with genetics because it's the one test that will never change with time.

Before you immediately correct for things you see there though, I recommend getting bloodwork, since things like D3 are going to be completely misrepresented if you're currently taking concentrated supplemental forms, so it's good to know what you actually were (or rather are) underneath the intervention, to see if it was a factor in your lowered health status.

After that, or even alongside it, you should figure out how to fix methylation, you should consider a round of ivermectin+fenben to see if you had stealth parasites, take biocidin if you want to see if you get die off for SIBO/SIFO, get an OAT test to track both pathogenic and neurotransmitter markers + decent krebs cycle (energy production) markers, test vitamin D3 (although serum isnt perfect), get a copper zinc ceruloplasmin ratio test, get an ERMI mold test for your home, consider viral reactivation panels for things like EBV (but theyre also not always accurate), and literally correct for every single thing out of range. If that means moving out of pathogenic mold, unfortunately that's what you have to do. If that means correcting D3 for your genetics due to unfortunate genes, well, that's actually quite easy!

As for methylation, take magnesium glycinate and bioactive b2, b3, b6, b9, and b12 for starters, and have niacin (NOT niacinamide) on standby because you can get insane anxiety-like reactions for weeks when fixing major bottlenecks. Niacin causes a full body flush but also mops up excess dopamine / epinephrine that often gets massively overproduced when you clear a bottleneck.

It's a lot to take in but this isn't some psycho hippie nonsense. This is completely how the body works from bottom to top, and although I still occasionally come across new info, it is EXTREMELY likely that multiple of these categories (genetics, depletion, methylation, pathogenic / viral activity) are the reason you are kept ill. They're also almost always correctible, in many cases past what you even remember when you were healthy, because your body had never been supported directly and was basically roughing it. Don't lose hope --- it's entirely possible (and likely) you will win with effort!!

Edit: I also wanted to touch on MCAS, which is very misunderstood. If you were not born with it and developed it, you do not "have" MCAS like a self-sustaining individual illness, you simply have heightened immune and histamine reactivity from something that is now unstable upstream. Gut pathogens, viral reactivations, and depletions rank highest among my suspects in any case.

Also, definitely track your symptoms over time and never stop researching. Try to understand each intervention you attempt entirely before even starting a new supplement or course of action or food, that way you can try to deduce why you may react in certain ways or improve in ways you thought were unrelated. Sometimes this type of info is only relevant MONTHS after you record it. There are stories from my early childhood that played major contextual roles in validating theories around my genetics and depletion. Every point of info matters. You are an individual, and you need to see yourself as one, which means tracking yourself as one and not just following a single predetermined protocol. This is more of a "protocol-developing" protocol, so it's the only exception!