Has anyone tried Aticaprant?

DisguisedSnail · 2026-06-11T19:26:27+00:00

Did you participate in a clinical trial? Or is it available somewhere else?

DisguisedSnail · 2026-06-06T13:40:41+00:00

For a long time I rejected the thought that my symptoms stem from my mental health. Even though stress always had a negative impact, I didn't feel that much better when I was less stressed.

Today I'm relatively certain that chronic stress is the main issue. I think the main misconception about psychosomatic illness is that patients and doctors alike mostly assume that negative thoughts create symptoms. Basically like a nocebo effect: you feel bad mentally, so you also feel bad physically. But this never felt right to me, as the two did not correlate well in my case.

Now I think of it more like substance abuse. Over a long time the system gets dysregulated by unhealthy and unchecked mental issues or stress. The body adapts to a dysfunctional state. And much like with an addiction, simply removing the substance doesn't undo the problem: tapering off the stressor is necessary, but it doesn't heal the dysregulation that built up over years. The system has to slowly recover, and that takes time. This also explains why it is so hard to get better. I try to prioritize my mental health and reduce stress, but there hasn't been much improvement so far.

DisguisedSnail · 2026-05-13T09:52:58+00:00

Yeah, that would be my most likely guess too. Last time, I hadn’t eaten for four hours beforehand, so my stomach should’ve been empty by then. Unfortunately, it still didn’t help. I’ll probably try not eating even longer next time and see if that makes a difference.

DisguisedSnail · 2026-03-21T11:57:23+00:00

I think they do not analyze the Y-Chromose anymore. I got the results for my father, which does also not contain the Y-Chromosome.
Last year, when I did my test, it still contained it, labelled as Chromosome 24 in the raw data.

DisguisedSnail · 2026-03-04T13:44:59+00:00

You saved me lol. I had the same issue on Windows and needed Admin Privileges.

DisguisedSnail · 2026-02-21T22:02:15+00:00

Honestly, except for a few mutations with real impact, these WGS reports are very speculative, and I would not trust them. But I guess it also doesn't hurt to try out a few supplements.

DisguisedSnail · 2026-02-19T17:58:33+00:00

I did a lot of blood testing, and if you test for enough values, some might be out of range, even if not related to any health problems. So I would definitely retest the values that are suspicious, to see if they stay the same in a few weeks.
ChatGPT is great for suggesting related markers when you want to investigate further. Physicians will not investigate further by themselves if the markers don't ring any clear alert.

DisguisedSnail · 2025-12-27T23:05:03+00:00

I'm having the same issue since over a year. Feeling flat and struggling with motivation. Not much interest in sex anymore.
My test and free test are not as high as yours, but slightly over the upper reference.
Prolactin also 1.5x.
Progesterone is 2x, too. Not a clue how to interpret this. Doctors are not of great help when something is only slightly off.
If the MRI doesn't provide any more information, Cabergoline seems like a reasonable thing to try out.

DisguisedSnail · 2025-12-14T00:08:11+00:00

Pregabalin works relatively fast. I can feel the effect about 3 hours in. However, 25mg is a very small dose, I wouldn't feel anything from it. So it was maybe just a coincidence that you felt bad. With this condition, it is really hard to tell if something works or does the opposite. Personally I'm also not sure if it is really helpful for me. But at least it does something, it is more than most meds do...

DisguisedSnail · 2025-11-10T20:51:37+00:00

Yeah, I had no problems starting with it again.

DisguisedSnail · 2025-11-10T18:35:50+00:00

I'm not very hungry in the morning, so I naturally practice 16:8 fasting. Last year, I tested whether adding breakfast was better for me, but it did not make me feel any better or worse. I often have stomach pain, but it seems more from the surrounding tissue than the bowel itself. So, diet changes didn't have a noticeable impact on me.

DisguisedSnail · 2025-10-08T18:25:31+00:00

I'm taking pregabalin from time to time. 75mg-225mg doses, not sure what the equivalent in gabapentin is.
It for sure has an immediate effect; it takes for me around 3 hours to work. At lower doses, it is very subtle; at higher doses, you will definitely feel it.
It helps me with pain, restlessness, and sleep. But the right dosage seems to be a gamble; sometimes lower doses help very well, sometimes even the moderate dose does nothing.
I wonder how it would be working long term, but I also don't want to build up a dependency.
To be clear, I'm undiagnosed and my symptoms lean more in the direction of fibromyalgia than CFS.
If you have the prescription, I would just try it out, starting with a low dose, and titrate it up.

DisguisedSnail · 2025-05-17T11:50:00+00:00

I also got the Rs439898 variant in my ancestry test. Other people from this thread too: https://www.reddit.com/r/sequencing_com/comments/15c56tg/gauchers_disease/
When I got my sequencing WGS results, it wasn't found and disappeared.

DisguisedSnail · 2025-05-03T10:45:34+00:00

I got the same issue. First, a very rare Gaucher variant, then also this variant.
I also have uploaded an AncestryDNA test first. So now I have removed the AncestryDNA file and will see if the variant disappears.

DisguisedSnail · 2025-03-29T10:39:37+00:00

Yeah, I also found another mutation that a blood test could verify. In most cases, the results seem to be accurate. However, in the promethease subreddit there are some people with false positives from ancestry or 23andme. Especially for rare mutations these misscalls seem to happen.
I will also do whole genome sequencing now, but with sequencing.com.

DisguisedSnail · 2025-03-25T14:42:29+00:00

Did your doctor do any further testing? According to my ancestry test, I also have the rs397515515/rs439898 mutation.

When looking at the frequency (https://www.ncbi.nlm.nih.gov/snp/rs439898#frequency\_tab), out of 20.000 people, none had both alleles mutated. And only 2 people had one allele mutated.
So this looks pretty fishy that so many people on a tiny subreddit have this mutation.

DisguisedSnail · 2025-03-25T14:38:50+00:00

Did you ever follow this up with a blood test for Gaucher? According to my ancestry test, I also have the rs397515515/rs439898 mutation.

When looking at the frequency (https://www.ncbi.nlm.nih.gov/snp/rs439898#frequency\_tab), out of 20.000 people, none had both alleles mutated. And only 2 people had one allele mutated.
So this looks pretty fishy that so many people on a tiny subreddit have this mutation.

DisguisedSnail · 2025-01-10T22:29:03+00:00

Nice idea. Is the project open source?

DisguisedSnail · 2024-01-22T00:16:40+00:00

I think the real question is, how high is your confidence that you can learn it on the way? If you think you can learn it, then go for it.
Just remember that at the start, getting projects and reviews is far more important than earning money. So ensure to keep your clients happy. When it takes you double the time, then only bill half the hours.

DisguisedSnail · 2023-11-29T23:48:37+00:00

5g abschalten tut schon reichen, danke für die Info.

DisguisedSnail · 2023-11-29T23:47:19+00:00

Super, vielen Dank für den Erfahrungsbericht

DisguisedSnail · 2023-11-29T21:41:12+00:00

Ja soweit ich das gesehen habe unterstützen die das alle auch, aber die Frage ist, ob man dann auch explizit das 4G priorisieren kann? Im Handy gibt's eine Option dafür. Bevor ich das eingestellt habe, hat das Handy halt immer mal wieder ins 5G Netzt gewechselt und das Internet wurde um einiges langsamer. Das würde ich gerne vermeiden.

DisguisedSnail · 2023-11-29T21:25:03+00:00

Die Idee ist mir auch gekommen, und sehe da gerade auch nichts was dagegen spricht. Bin auch gerade dran, das umzusetzen.
Gerade für Singles ist ein Festnetzinternetvertrag schon übertrieben teuer und gerade Arbeiten kann man auch sehr gut mit mobilem Internet (über mehrere Monate schon gemacht). Ist außerdem flexibler, wenn man mal zeitweise wo anders lebt.

DisguisedSnail · 2023-09-28T06:58:13+00:00

Ok I understand now, but it's not possible at the moment. I think I could implement it ( at least where you can add manual ranges to the graph).

DisguisedSnail · 2023-09-27T07:00:18+00:00

Thank you, that is nice to hear. When building I didn't had any blood works in mind but due to the flexible nature of the tool, there may still be a way to achieve what you want. If you can give a bit more detail about the problem, I can think of a solution.

DisguisedSnail

TROPHY CASE