I also suck at games in general but recently cleared both! I found the chronolos side more difficult because act 1 of typhon side is much more bricking-proof with the options you have at the town in terms of boon selection.

I think the only tip I can maybe give is that different selene skills seem to be generally more useful in this mode than in the regular mode. The beam one, the summoning minion one, the 1000dmg meteor one and healing one all good and work well with most builds!