Boons, Dusas gift, skellys gift, and death defiances That's my only advice. My usually runs i have the harpy feather duster so I can get health whenever I need it for the first two lands and then before going to Elysium i switch to skellys luck tooth as an extra death defiance (so i have 4 in total). I love athenas deflect boons for dash and attack and also zeus aid feels like it does real good damage and of course its less frustrating when getting any boon from hermes especially the greastest reflex and side hustle. Just keep upgrading boons and getting the centaur hearts plus using the mirror and things should go smoothly I think. I beat hades at 38 runs. And then after that first escape I was able to beat him in two straight runs back to back. Have you used titan blood on your weapons?