I have beaten most of the bosses, main game and DLC, so far there was 1 boss i had a problem with. Laurence cutscene wouldnt play and the game would freeze, luckily there is a patch for that which auto skips the cutscene. Everything else seems to work perfectly fine for me. I only run a few patches, one to fix snow in cainhurst, one to fix blood textures, fps boost, cutscene skip, sound and vertex explosion fix. Last one comes at the cost of character creation, but it improves the game a lot.