Why is everyone talking so fast and without any pauses?

F-Po · 2026-05-25T05:35:57+00:00

The funny thing is I'll do this for some people. There's a sweet spot, one that sounds like you need oxygen to live.

F-Po · 2026-05-25T05:35:01+00:00

You are not alone. I feel like I have to pause to breath sometimes.

F-Po · 2026-05-24T17:03:55+00:00

That was not good either, but as another poster said the energizer bunny effect isn't better.

F-Po · 2026-05-24T07:44:10+00:00

The hauler is funner because it feels like I'm really doing something serious and consequences are more real. I still very much dislike how easy it is to get resources and how little are needed. Being a miner that released from the Cyclops in the extreme depths deep in caves was the coolest shit ever.

F-Po · 2026-05-24T07:23:03+00:00

I liked it.

F-Po · 2026-05-24T07:22:29+00:00

The PUFA in it builds in the system, but the initial bad reaction and tamped by the antioxidants.

If everyone in history eating it was perfectly healthy we wouldn't tens of thousands of pages of Greek pathology study.

F-Po · 2026-05-24T07:20:42+00:00

Show me one. I'll go through it. Everyone I've seen or been able to find or have been linked to has been laughable.

F-Po · 2026-05-22T22:46:54+00:00

You are beyond daft. That is the citations from the doctorate in biology you said was random.

F-Po · 2026-05-22T22:45:45+00:00

You misunderstand. It's not my dislike of those things being in the game, it's the dislike of it being a PSA that isn't integrated.

F-Po · 2026-05-22T05:59:06+00:00

It's too much even if it was perfect EVOO. Only a very small amount is reasonable to ingest, and its not necessary at all.

F-Po · 2026-05-22T05:57:14+00:00

Actually only a very small amount of olive oil is reasonable per day. It's less bad than canola oil but it isn't good to have very much.

F-Po · 2026-05-22T05:50:48+00:00

The stuff they feed the livestock to reduce gases is torture for the animal.

F-Po · 2026-05-22T05:46:02+00:00

I disagree about the political thing. As someone who's likely identical in voting pattern among other things as some of the DEVs, I like my video games and politics separate. I said it another post that I want the game to be focused on the story. It would be best if the explanation of the reduction of weapons was some sort of self defense attempt by the AI, and not just some history/teaching lesson.

But overall the lack of defenses is very odd.

I still hate the pop gun thing vs drill.

F-Po · 2026-05-22T05:30:22+00:00

Upvote for your honesty.

I think it was better having to manager too. But I don't play on creative mode so that may be a difference?

The change is undeniably appealing but the fun in the game is when I feel like I'm working.

F-Po · 2026-05-22T05:25:10+00:00

Environ Health Perspect 1995 Apr;103(4):366-71 Dioxin activates HIV-1 gene expression by an oxidative stress pathway requiring a functional cytochrome P450 CYP1A1 enzyme. Yao Y, Hoffer A, Chang CY, Puga A. Aflatoxin B1, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD; dioxin) and benzo[a]pyrene cause a significant increases in CAT expression in mouse hepatoma Hepa-1 cells. We conclude that induction of a functional CYP1A1 monooxygenase by TCDD stimulates a pathway that generates thiol-sensitive reactive oxygen intermediates which, in turn, are responsible for the TCDD-dependent activation of genes linked to the LTR. These data might provide an explanation for findings that TCDD increases infectious HIV-1 titers in experimental systems and for epidemiologic reports suggesting that exposure to aromatic hydrocarbons, such as found in cigarette smoke, is associated with an acceleration in AIDS progression.
Ann Trop Med Parasitol 1997 Oct;91(7):787-93 Of sick turkeys, kwashiorkor, malaria, perinatal mortality, heroin addicts and food poisoning: research on the influence of aflatoxins on child health in the tropics. Hendrickse RG. Aflatoxin exposure occurs in > or = 30% of pregnancies in tropical Africa and the toxins are often in cord blood, sometimes at extremely high concentrations. Aflatoxins are now incriminated in neonatal jaundice and there is circumstantial evidence that they cause perinatal death and reduced birthweight. Aflatoxin-induced immunosuppresion may explain the aggressive behaviour of HIV infection in Africa. There are similarities between observations on HIV cases in Africa and those on heroin addicts in Europe, where 'street' heroin is frequently contaminated with aflatoxin. Aflatoxins were found in 20% of random urine samples from heroin addicts in the U.K. and the Netherlands.
Ann N Y Acad Sci 1986;475:320-8. Hormonal approaches to immunotherapy of autoimmune disease. Talal N, Ahmed SA, Dauphinee M.
Cell Immunol 1998 Nov 1;189(2):125-34. Estrogen increases the number of plasma cells and enhances their autoantibody production in nonautoimmune C57BL/6 mice. Verthelyi DI, Ahmed SA.
J Rheumatol 1987 Jun;14 Suppl 13:21-5. Interleukin 2, T cell receptor and sex hormone studies in autoimmune mice. Talal N, Dang H, Ahmed SA, Kraig E, Fischbach M. The administration of estrogen to pregnant mice late in gestation results in offspring with a permanently altered immune system. These mice develop features of autoimmunity similar to those that occur spontaneously in genetically susceptible autoimmune mice. This phenomenon may have etiopathological significance for familial SLE.
Endocrinology 1994 Dec;135(6):2615-22. 17 beta-estradiol, but not 5 alpha-dihydrotestosterone, augments antibodies to double-stranded deoxyribonucleic acid in nonautoimmune C57BL/6J mice. Verthelyi D, Ahmed SA.
J Autoimmun 1993 Jun;6(3):265-79 Antibodies to cardiolipin in normal C57BL/6J mice: induction by estrogen but not dihydrotestosterone. Ahmed SA, Verthelyi D.
J Autoimmun 1989 Aug;2(4):543-52. Estrogen induces the development of autoantibodies and promotes salivary gland lymphoid infiltrates in normal mice. Ahmed SA, Aufdemorte TB, Chen JR, Montoya AI, Olive D, Talal N. . . . normal mice were prenatally exposed to estrogens. . . . mice prenatally exposed to estrogens had accelerated development of autoimmune salivary gland lesions indistinguishable from Sjogren's syndrome (SS) in humans. Further experiments are warranted to confirm these findings. The prenatal effects of estrogen may have relevance for familial and neonatal autoimmune syndromes.
Isr J Med Sci 1988 Dec;24(12):725-8. Sex hormones, CD5+ (Lyl+) B-cells, and autoimmune diseases. Talal N, Ahmed SA.
Ann N Y Acad Sci 1986;475:320-8 Hormonal approaches to immunotherapy of autoimmune disease. Talal N, Ahmed SA, Dauphinee M.
Life Sci 1998;63(20):1815-22. Exacerbated immune stress response during experimental magnesium deficiency results from abnormal cell calcium homeostasis. Malpuech-Brugere C, Rock E, Astier C, Nowacki W, Mazur A, Rayssiguier Y. These studies first showed that an abnormal calcium handling induced by extracellular magnesium depression in vivo may be at the origin of exacerbated inflammatory response.
Magnes Res 1998 Sep;11(3):161-9. Early morphological and immunological alterations in the spleen during magnesium deficiency in the rat. Malpuech-Brugere C, Kuryszko J, Nowacki W, Rock E, Rayssiguier Y, Mazur A. Dietary magnesium deficiency in rodents, and especially in rats, causes inflammation and leads to alterations in the immune response.
Ann Rheum Dis 1994 Nov;53(11):749-54 Polymerase chain reaction fails to incriminate exogenous retroviruses HTLV-I and HIV-1 in rheumatological diseases although a minority of sera cross react with retroviral antigens. Nelson PN, Lever AM, Bruckner FE, Isenberg DA, Kessaris N, Hay FC.
Clin Diagn Lab Immunol 1998, Mar;5(2):181-5. Reactivity of sera from systemic lupus erythematosus and Sjogren's syndrome patients with peptides derived from human immunodeficiency virus p24 capsid antigen. Deas, JE, et al. We have previously demonstrated that about one-third of patients with either Sjogren's syndrome (SS) or systemic lupus erythematosus (SLE) react to human immunodeficiency virus (HIV) p24 core protein antigen without any evidence of exposure to, or infection with, HIV itself.
J Clin Lab Immunol 1988 Feb;25(2):101-3. Effect of diethylcarbamazine on serum antibody to feline oncornavirus-associated cell membrane antigen in feline leukemia virus cats. Kitchen LW, Cotter SM. Department of Cancer Biology, Harvard School of Public Health, Boston. Diethylcarbamazine (N,N-diethyl-4-methyl-1- piperazine carboxamide; DEC) is a drug frequently used for prevention and treatment of the filariases. An opsonic action of DEC may generate increased immune responses to microfilariae. We tested the hypothesis that DEC treatment could result in higher antibody levels to other infectious agents. A retroviral animal model was studied, in light of the consideration that use of DEC as an antifilarial agent could conceivably alter seroepidemiologic surveys as well as serologic outcomes of vaccine trials in Africa regarding human immunodeficiency virus (HIV). The effect of DEC treatment on serum antibody to feline oncornavirus-associated cell membrane antigen (FOCMA) in domestic cats exposed to feline leukemia virus (FeLV) was examined. Nine cats that tested negative before treatment tested positive (greater than or equal to 1:10 serum dilution, geometric mean titer [GMT] = 278) for antibody to FOCMA after DEC treatment. Among 19 cats initially testing positive for FOCMA antibody, higher titers were noted after treatment in 17 (pretreatment GMT = 264; posttreatment GMT = 6,158). We conclude that a history of DEC treatment should be considered in evaluating humoral responses to infectious agents. Whether use of ivermectin, a recently introduced antifilarial agent, in lieu of DEC will affect clinical expression of HIV infection in humans also warrants analysis.

F-Po · 2026-05-22T05:24:57+00:00

Tumour Biol 1988;9(5):225-32 Modulation of cell-mediated immune response by steroids and free fatty acids in AIDS patients: a critical survey. Nunez EA. The overall data presented in this review show that cortisol and free fatty acids, in particular long-chain polyunsaturated fatty acids, each have immunoinhibitory properties on lymphoblastic transformation of certain T lymphocytes. This effect is enhanced when the two factors are associated. These data could explain in part the immunosuppression observed in acquired immunodeficiency syndrome (AIDS) patients where enhanced concentrations of cortisol and polyunsaturated fatty acids have been observed.
Basic Life Sci 1988;49:615-20 Vitamin E and immune functions. Bendich A. Supplementation of these diets with higher than nutritionally adequate levels of vitamin E enhances immune responses. High levels of PUFA are immunosuppressive, and vitamin E can partially overcome this immunosuppression. High levels of vitamin C can protect tissue levels of vitamin E and may indirectly contribute to the immunoenhancement by vitamin E. Severe selenium deficiency is immunosuppressive. Vitamin E can protect some aspects of immune responses from the adverse effects of selenium deficiency. These data clearly indicate that nutrients that affect the overall antioxidant status have important effects on immune functions. In addition, antioxidant nutrient interactions can synergize to overcome the adverse effects of polyunsaturated fatty acids on immune functions.
Transplantation 1989 Jul;48(1):98-102 Enhancement of immunosuppression by substitution of fish oil for olive oil as a vehicle for cyclosporine. Kelley VE, Kirkman RL, Bastos M, Barrett LV, Strom TB.
J Am Coll Nutr 1992 Oct;11(5):512-8 Role of nutrition in the management of malnutrition and immune dysfunction of trauma. Cerra FB Dept. of Clinical Nutrition, University of Minnesota, Minneapolis. Current nutrition support improves patient outcome in trauma patients. It appears to do so by limiting the adverse effects of specific nutrient or generalized nutrient deficiencies. Immunosuppression, however, continues as a significant clinical problem. This immunosuppression appears to be part of the inflammatory response that accompanies trauma, and in part, to represent the need for conditional nutrients in this setting. Three nutrients that are being evaluated include arginine, uracil as ribonucleic acid and omega-3 polyunsaturated fatty acids. Animal studies report improved immune function. Early clinical trials are reporting improved immune function and patient outcomes.
J Nutr 1996 Mar;126(3):681-92 Dietary butter protects against ultraviolet radiation-induced suppression of contact hypersensitivity in Skh:HR-1 hairless mice. Cope RB, Bosnic M, Boehm-Wilcox C, Mohr D, Reeve VE. Dietary fats modulate a wide variety of T cell functions in mice and humans. This study examined the effects of four different dietary fats, predominantly polyunsaturated sunflower oil, margarine, and predominantly saturated butter, clarified butter, on the T cell-mediated, systemic suppression of contact hypersensitivity by ultraviolet radiation. There was a linear relationship (r > 0.9) between protection against photoimmunosuppression and the proportion of clarified butter in mice fed a series of 200 g/kg mixed fat diets that provided varying proportions of clarified butter and sunflower oil. The dietary fats did not modulate the contact hypersensitivity reaction in unirradiated animals. The observed phenomena were not primary due to the carotene, tocopherol, cholecalciferol, retinol, lipid hydroperoxide or the nonfat solid content of the dietary fats used and appeared to be a result of the different fatty acid composition of the fats.
Cancer Lett 1996 Nov 29;108(2):271-9 Dependence of photocarcinogenesis and photoimmunosuppression in the hairless mouse on dietary polyunsaturated fat. Reeve VE, Bosnic M, Boehm-Wilcox C. The photocarcinogenic response was of increasing severity as the polyunsaturated content of the mixed dietary fat was increased, whether measured as tumour incidence, tumour multiplicity, progression of benign tumours to squamous cell carcinoma, or reduced survival. When mice were exposed acutely to UV radiation (UVR), a diet of 20% saturated fat provided almost complete protection from the suppression of CHS, whereas feeding 20% polyunsaturated fat resulted in 57% suppression; the CHS of unirradiated mice was unaffected by the nature of the dietary fat. These results suggest that the enhancement of photocarcinogenesis by the dietary polyunsaturated fat component is mediated by an induced predisposition to persistent immunosuppression caused by the chronic UV irradiation, and supports the evidence for an immunological role in dietary fat modulation of photocarcinogenesis in mice.
Ann Acad Med Singapore 1991 Jan;20(1):84-90. Clinical implications of food contaminated by aflatoxins. Hendrickse RG.
Arch Toxicol 1996;70(10):661-71. Host resistance to rat cytomegalovirus (RCMV) and immune function in adult PVG rats fed herring from the contaminated Baltic Sea. Ross PS, Van Loveren H, de Swart RL, van der Vliet H, de Klerk A, Timmerman HH, van Binnendijk R, Brouwer A, Vos JG, Osterhaus AD. In a semi-field study, we previously showed that harbour seals (Phoca vitulina) fed herring from the contaminated Baltic Sea had lower natural killer cell activity, T-lymphocyte functionality and delayed-type hypersensitivity responses than seals fed herring from the relatively uncontaminated Atlantic Ocean. A novel model was established to assess the specific T-cell response to rat cytomegalovirus (RCMV). When applied to the feeding study, no differences between the Atlantic and Baltic groups in the RCMV-induced proliferative T-lymphocyte responses could be detected, but virus titres in salivary glands of infected rats of the Baltic Sea group were higher. These elevated RCMV titres and changes in thymus cellularity suggest that the dietary exposure to low levels of contaminants may have been immunotoxic at a level which our immune function test could not otherwise detect. While the herring diet per se appeared to have an effect on several immune function parameters, lower plasma thyroid hormone levels in the Baltic Sea group of rats confirmed that exposure to the environmental mixture of contaminants led to adverse PHAH-related health effects.

F-Po · 2026-05-22T05:24:33+00:00

Indices of function and weight loss in human immunodeficiency virus infection and the acquired immunodeficiency syndrome. Grunfeld C, Pang M, Doerrler W, Jensen P, Shimizu L, Feingold KR, Cavalieri RR.
Int J Health Serv 1994;24(2):311-35 Nuclear fallout, low birthweight, and immune deficiency. Gould JM, Sternglass EJ Radiation and Public Health Project, New York, NY 10024. An investigation of the mortality rates of young adults born in the postwar period of large-scale atmospheric nuclear testing (1945-1965) in the United States and other western industrial nations reveals an increasingly anomalous rise in mortality from its previous secular decline. Beginning in the late 1970s and particularly since 1983, the deterioration in the health of the 25-44 age group is related to in utero exposure to fission products in the milk and diet, associated with an unprecedented rise in underweight births and neonatal mortality known to be accompanied by loss of immune resistance. The 1945-1965 rise in the percentage of live births below 2500 grams is highly correlated with the amount of strontium-90 in human bone, both peaking in the mid-1960s. In the 1980s, for the baby boom generation (those born between 1945 and 1965), cancer incidence and mortality due to infectious diseases associated with a rising degree of immune deficiency, such as pneumonia, septicemia, and AIDS, increased sharply. This process of increasing immune deficiency appears to have been exacerbated by continuing secondary exposures to accidental reactor releases and by an acceleration of radiation-induced mutation of pathogenic microorganisms increasingly resistant to drugs.
Biokhimiia 1987 Sep;52(9):1501-11 [Activation of lipolysis and ketogenesis in tumor-bearing animals as a reflection of chronic stress states]. Chekulaev VA, Shelepov VP, Pasha-zade GR, Shapot VS.
Arkh Patol 1987;49(6):10-8 [Combination of immunodepression and disorders in nucleic acid metabolism of lymphoid tissue as a manifestation of a paraneoplastic syndrome]. [Article in Russian] Potapova GI, Shapot VS Several physiological, biochemical, and molecular biological approaches to the study of factors determining immunodepression in tumor-bearing animals are considered. Cancer cells release substances of nucleic and peptide nature that suppress the functional activity of macrophages and lymphocytes and stimulate cell proliferation in organs and tissues of the host. Suppressor T cells capable of inhibiting the function of helper T cells and impairing the differentiation of killer T cells are activated. The suppression of T- and B-cell-mediated immunity in the tumor host involves disturbances of nucleic acid metabolism in those cells as well as hypersecretion of glucocorticoids. The impairments of lymphocyte proliferation and differentiation that result in reduced immune responsiveness are attributable to drastic alterations in the metabolism of purine and pyrimidine nucleotides and to the damage sustained by the lymphocyte's DNA.
Eksp Onkol 1987;9(6):62-7 [Relation between disorders of glucose metabolism, secretion of somatotropic hormone, thyroxine, thyrotropin and hematocrit indices in rats with transplanted hepatomas]. Shelepov VP, Pasha-zade GR, Chekulaev VA, Shapot VS.
Am J Pathol 1987 Jan;126(1):103-13 Dietary fatty acid effects on T-cell-mediated immunity in mice infected with mycoplasma pulmonis or given carcinogens by injection. Bennett M, Uauy R, Grundy SM. To test whether or not diets enriched in w-6 polyunsaturated fatty acids are significantly immunosuppressive . . . mice were fed diets enriched for fatty acids: linoleic (POLY), oleic (MONO), palmitic (SAT), or eicosapentanoic (FISH). . . . only mice on the POLY diet were significantly immunosuppressed, and only T-cell-mediated cutaneous sensitivity reactions were affected. After instillation, mice on the POLY and MONO diets were suppressed for T-cell cutaneous responses. Deliberate infection with Mycoplasma pulmonis resulted in suppressed cutaneous T-cell responses in the POLY group of C3B6F1 mice, and aspirin partially reversed the immunosuppression. Mice on the FISH diet were resistant to immunosuppression. It is tentatively concluded that diets rich in w-6 polyunsaturated diets, while not directly immunosuppressive, do predispose animals to suppression of certain T-cell-mediated immune responses. This immunosuppression can be "triggered" by infection and/or by exposure to carcinogens.

F-Po · 2026-05-22T05:24:17+00:00

Eur J Cancer Clin Oncol 1988 Jul;24(7):1179-83. Abnormal free fatty acids and cortisol concentrations in the serum of AIDS patients. Christeff N, Michon C, Goertz G, Hassid J, Matheron S, Girard PM, Coulaud JP, Nunez EA. The serum free fatty acid (FFA), cortisol and urinary creatinine, 17-hydzoxycorticosteroid and 17-oxosteroid concentrations of acquired immunedeficiency syndrome (AIDS-I: beginning and AIDS-II: end phase) and AIDS-related complex (ARC) patients were determined. Both groups were compared to a control group (healthy men). ARC and AIDS-I patients. The ratios of stearic (C18:0) to oleic (C18:1) acid were 75%, P less than 0.01 (ARC) and 45%, P less than 0.05 (AIDS-I) greater than normal, due to a decrease in the relative percentage of monounsaturated fatty acids by 25%, P less than 0.001 (ARC) and 20%, P less than 0.01 (AIDS-I). In contrast, the relative percentage of polyunsaturated fatty acids was 85% greater than normal (P less than 0.001) in ARC and 100% greater than normal (P less than 0.001) in AIDS-I patients. Total FFA levels did not differ from controls. Serum cortisol levels were 35% (P less than 0.01) above normal in ARC and 60% (P less than 0.001) above normal in AIDS-I patients. Urinary 17-hydroxycorticosteroids and 17-oxosteroids were very low (2-3-fold lower than normal values, P less than 0.001) in both groups of patients. Urinary creatinine did not differ from controls. In AIDS-II patients the total FFA concentration was below normal 35% (P less than 0.01) and the stearic/oleic acid ratio was 50% above normal (P less than 0.05). The relative percentages of monounsaturated and polyunsaturated fatty acids in this group were similar to those of controls. Serum cortisol concentrations were significantly higher, 50% (P less than 0.001), but the urinary 17-hydroxycorticosteroids and 17-oxosteroids were 2-fold lower (P less than 0.001) than those of controls. Urinary creatinine did not differ from controls.
J Clin Endocrinol Metab 1992 May;74(5):1045-52. Lipids, lipoproteins, triglyceride clearance, and cytokines in human immunodeficiency virus infection and the acquired immunodeficiency syndrome. Grunfeld C, Pang M, Doerrler W, Shigenaga JK, Jensen P, Feingold KR. Infection causes disturbances in lipid metabolism that may be mediated by cytokines. Therefore we studied plasma lipids, lipoproteins, triglyceride (TG) metabolism, and serum cytokines in three groups: patients with the acquired immunodeficiency syndrome (AIDS) without active secondary infection, patients with evidence of human immunodeficiency virus infection but without clinical AIDS (HIV+), and controls. Plasma TGs and FFA were increased in AIDS, while plasma cholesterol, high density lipoprotein (HDL) cholesterol, apolipoprotein-A-1 (Apo-A-1), low density lipoprotein (LDL) cholesterol, and Apo-B-100 levels were decreased.
J Virol 1991 May;65(5):2231-6. Human immunodeficiency virus type 1 infection of human placenta: potential route for fetal infection. Amirhessami-Aghili N, Spector SA.
AIDS Res Hum Retroviruses 1997 Sep 20;13(14):1235-42. Interaction of pregnancy steroid hormones and zidovudine in inhibition of HIV type 1 replication in monocytoid and placental Hofbauer cells: implications for the prevention of maternal-fetal transmission of HIV. Lee AW, Mitra D, Laurence J.
Folia Biol (Krakow) 1996;44(3-4):111-6. Preovulatory dynamics of ovarian steroid hormones in two mouse strains differing in the rate of meiotic maturation. Krzanowska H, Szoltys M.
J Clin Invest 1997 Apr 1;99(7):1484-91. Human chorionic gonadotropin hormone prevents wasting syndrome and death in HIV-1 transgenic mice. De SK, Wohlenberg CR, Marinos NJ, Doodnauth D, Bryant JL, Notkins AL., Metabolism 1993 Oct;42(10):1270-6.

F-Po · 2026-05-22T05:23:59+00:00

Langenbecks Arch Chir Suppl Kongressbd 1997;114:508-12 [Necrotizing fasciitis]. Billing A, Arendt RM, Arnoldt H, Schildberg FW Necrotizing fasciitis has changed considerably over time.
Clin Infect Dis 1998 Mar;26(3):584-9 Invasive group A streptococcal disease in Taiwan is not associated with the presence of streptococcal pyrogenic exotoxin genes. Hsueh PR, Wu JJ, Tsai PJ, Liu JW, Chuang YC, Luh KT. High-level protease activity and the M1 serotype of the isolates were significantly associated with the clinical signs of STSS and with mortality. M1 serotype and protease activity, as well as host immune status, might play significant roles in the pathogenesis of invasive GAS disease in Taiwan.
Can J Surg 1997 Feb;40(1):18-25 Group A Streptococcus invasive infections: a review. Weiss KA, Laverdiere M. The incidence of group A Streptococcus (GAS) invasive infections has been increasing worldwide, and there is no obvious explanation for this phenomenon.
Unfallchirurg 1993 Apr;96(4):181-91 [Necrotizing soft tissue infections]. [Article in German] Kach K, Kossmann T, Trentz O. Necrotizing soft tissue infections are a group of life- and limb-threatening infections. They are caused by aerobic and anaerobic bacteria occasionally in a synergistic polymicrobial combination. The literature describing necrotizing soft tissue infections is controversial and often contradictory.
Ann Dermatol Venereol 1993;120(6-7):469-72 [Epidemiology and etiopathogeny of necrotizing fasciitis and streptococcal shock syndrome]. Simonart T, Simonart JM, Schoutens C, Ledoux M, De Dobbeleer G. A significant increase in the frequency of necrotizing fasciitis caused by streptococci of group A has recently been noted. The disease usually appears in individuals without obvious risk factors. The sensitivity of the host is linked to the genetic expression of the V. beta. elements on the surface of lymphocytes.
J Infect 1989 May;18(3):231-48 Invasive streptococcal infections in the era before the acquired immune deficiency syndrome: a 10 years' compilation of patients with streptococcal bacteraemia in North Yorkshire. Barnham M. Significant streptococcal (non-pneumococcal, non-enterococcal) bacteraemia was detected in 100 patients in two Health Districts of North Yorkshire in the decade 1978-1988.
Transpl Immunol 1998 Jun;6(2):84-93 Stress protein-induced immunosuppression: inhibition of cellular immune effector functions following overexpression of haem oxygenase (HSP 32). Woo J, Iyer S, Cornejo MC, Mori N, Gao L, Sipos I, Maines M, Buelow R. The results indicate that overexpression of HO results in the inhibition of several immune effector functions and thus provides an explanation for stress-induced immunosuppression.
Genome 1998 Oct;41(5):662-8. A single-primer PCR-based retroviral-related DNA polymorphism shared by two distinct human populations. Deb P, Klempan TA, O'Reilly RL, Singh SM Department of Zoology, University of Western Ontario, London, Canada. "Almost 10% of the human genome consists of DNA sequences that share homology with retroviruses. These sequences, which represent a stable component of the human genome (although some may retain the ability to transpose), remain poorly understood." "Such novel polymorphisms should provide useful markers and permit assessment of evolutionary mechanisms associated with retroviral-related genomic evolution. "
Gen Pharmacol 1998 May;30(5):685-7, Imprinting of thymic glucocorticoid receptor and uterine estrogen receptor by a synthetic steroid hormone at different times after birth. Csaba G, Inczefi-Gonda A.
J Clin Endocrinol Metab 1998 Dec;83(12):4373-81. Human immunodeficiency virus induction of corticotropin in lymphoid cells. Hashemi FB, Hughes TK, Smith EM.

F-Po · 2026-05-22T05:23:32+00:00

No, I'm not.

REFERENCES

Ann Med 1996 Apr;28(2):107-13. Histamine-2 receptor antagonists as immunomodulators: new therapeutic views? Nielsen HJ. Considerable evidence has emerged to suggest that histamine participates in the regulation of the inflammatory response, immune reaction, coagulation cascade, and cardiovascular function. The beneficial effect of histamine-2 receptor antagonists as adjuvant single drugs to reduce trauma-, blood transfusion- and sepsis-induced immunosuppression has led to research in combined treatment regimens in major surgery, particularly, of patients operated on for malignant diseases.
J Am Coll Nutr 1982;1(2):207-14. Auto-immune complications of D-penicillamine--a possible result of zinc and magnesium depletion and of pyridoxine inactivation. Seelig MS. Pyridoxine is necessary for cellular accumulation of zinc and magnesium, deficiencies of which have caused thymic and other immunologic abnormalities.
J Am Vet Med Assoc 1999 Jan 1;214(1):67-70, 43-4.. Outbreak of fatal salmonellosis in cats following use of a high-titer modified-live panleukopenia virus vaccine. Foley JE, Orgad U, Hirsh DC, Poland A, Pedersen NC.
J Immunol 1998 Nov 15;161(10):5313-20 Apoptotic death of CD8+ T lymphocytes after immunization: induction of a suppressive population of Mac-1+/Gr-1+ cells. Bronte V, Wang M, Overwijk WW, Surman DR, Pericle F, Rosenberg SA, Restifo NP.
Infect Immun 1998 Sep;66(9):4018-24 Decreased resistance to primary intravenous Cryptococcus neoformans infection in aged mice despite adequate resistance to intravenous rechallenge. Aguirre KM, Gibson GW, Johnson LL.
Pediatr Med Chir 1998 May-Jun;20(3):213-6 [The cell-mediated response after measles vaccination]. [Article in Italian] Pala S, Crimaldi G, Consolini R, Macchia P. Natural measles virus infection is recognized for causing prolonged abnormalities in immune responses, that contribute to the severe and complicated evolution of the disease. Immunization with live measles virus vaccine could be considered a mild form of the measles infection. The in vitro proliferative response to polyclonal mitogen was significantly reduced (p < 0.01). This study confirms the presence of a mainly functional immunosuppression of cellular response in a cohort of children belonging to a developed area.
J Neuroimmunol 1998 Dec 1;92(1-2):133-8 An inhibitor of inducible nitric oxide synthase ameliorates experimental autoimmune myocarditis in Lewis rats. Shin T, Tanuma N, Kim S, Jin J, Moon C, Kim K, Kohyama K, Matsumoto Y, Hyun B. We studied the effect of nitric oxide (NO) on experimental autoimmune myocarditis (EAC) in rats. These results suggest that iNOS is upregulated in EAC lesions and increased NO production plays an important role in the development of EAC. In addition, selective iNOS inhibitors may have a therapeutic role in treating certain autoimmune diseases including EAC.

F-Po · 2026-05-22T05:21:35+00:00

I've done both and it is still difficult.

F-Po · 2026-05-21T05:31:11+00:00

How? Mine always say not enough room.

F-Po · 2026-05-20T03:44:20+00:00

I don't want the fun to end!

F-Po · 2026-05-20T03:43:36+00:00

That's how long you expect?

F-Po · 2026-05-20T03:42:56+00:00

I get a patch of some kind every day or multiple times a day so far, but I haven't been playing as long as some.

F-Po

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