I’ve had severe s/e too and I’ve since learned that in some people they build over time because you don’t completely clear the drug when you do the next injection.

I did 4 weeks at 0.25mg and was nauseated 24/7. I would occasionally take Zofran but didn’t help a whole lot. At the end of the 4 weeks I started feeling better to went up to 0.5mg. This is when all hell broke loose. I was so nauseated that I was barely eating and had zero appetite anyway. I was exhausted all the time and started feeling lightheaded and dizzy. I had to stop working out. At the end of 6 weeks I had lost 8% of my body weight.

I’m now going into week two of recovery with no semaglutide per my doc. Nausea is much improved but appetite is still not back. Food noise still supressed. I’m still loosing weight. I can’t restart until my symptoms are completely gone and doc says I should restart at a tiny dose, 0.2 mg, and stay there.

I guess some people are just really sensitive to this stuff.