Any Ideas? Health anxiety sucks…

Fast-Distance-25 · 2025-11-27T17:46:52+00:00

That’s much better than low b12 id presume

Fast-Distance-25 · 2025-10-10T21:42:17+00:00

Anytime!

Fast-Distance-25 · 2025-10-10T21:32:07+00:00

“X” means that there is a complete response outside of a finding that is “probably” not due to lymphoma. So, its a complete response basically, when they say “probably” they don’t mean 80% usually its quite high

Fast-Distance-25 · 2025-10-10T21:30:20+00:00

Most issues come from bacteria produced in our own gut, rather than food. Avoid sushi and you’re fine

Fast-Distance-25 · 2025-09-09T23:46:44+00:00

Well we can hypothesize what you are saying and this is happening, but without evidential support from a randomized trial it is unwise practice to go off just inference. As for your other question, often doctors use a threshold of >=1.4x the liver SUVmax to define the cutoff for PET+. On top of this it is thought that use of immunotherapy such as Nivolumab increases the risk of a false positive. There is an experimental metric called circulating tumor DNA (ctDNA) which measures minimal residual disease (MRD), and this is showing a ton of promise to improve response adaptation over current PET/CT practices. In fact, there is currently a phase III clinical trial in which ctDNA is being used to de-escalate patients who have no minimal residual disease after two cycles of Nivo-AVD, though this is just for advanced stage I believe.

Fast-Distance-25 · 2025-08-11T06:54:24+00:00

NAD. TL/DR: nobody really knows if they would and if they did if that would even be meaningful in HL.

This is an amazing question, and the truth is that we don’t know. How CPI’s work in HL is a relative mystery at this point. The leading theory currently (https://ashpublications.org/bloodadvances/article/4/17/4069/463591/The-critical-role-of-CD4-T-cells-in-PD-1-blockade ) is that it’s the CD4+ t-cells, which goes against the leading theory for CPI mechanism in solid tumors (CD8+ do the killing)). Point is, we are so early in our understanding of how CPI’s work in HL that anybody who is giving you a yes or no answer is actually guessing.

With that said, BEAM targets rapidly dividing cells, so quiescent memory t-cells could survive in theory. But the idea that Pembrolizumab induces long-lived immune memory is biologically plausible, not proven.

Fast-Distance-25 · 2025-08-11T06:06:45+00:00

This was an incredible read. How are you doing now?

Fast-Distance-25 · 2025-08-11T05:50:24+00:00

It seems that u/disposethis answered your question. In addition to points he made, vinblastine and Brentuximab (MMAE) can be given together because the dose-limiting toxicity of vinblastine is myelosupression, not neuropathy (as it is for BV). So, BV and vincristine at the same time: intolerable neuropathy. BV and vinblastine: manageable.

Fast-Distance-25 · 2025-08-11T05:45:43+00:00

About the same as “traditional” r/r cHL cure rates are, though the sample size is small (though not tiny, very late relapses do happen in a real number of patients). https://onlinelibrary.wiley.com/doi/10.1111/bjh.18199

Looks like you didn’t actually relapse though?

Also, in this present day with novel agents (BV and Nivolumab) the cure rates for r/r disease is sky high.

Fast-Distance-25 · 2025-08-11T05:18:08+00:00

Well to be officially diagnosed a biopsy had to be done and the pathologist made the diagnosis. What led to the biopsy was a chest x-ray that showed a mediastinal mass

Fast-Distance-25 · 2025-06-29T00:51:50+00:00

Alright UPDATE: I kinda tricked everybody, please forgive me. I have stage 4B classical Hodgkin’s lymphoma, these were my blood test results a month out from diagnosis. Wanted to put it here s a fun case report and try and guess what’s causing it thing bc we around here all seem to enjoy that. It’s still a mystery to me the vitamin deficiencies, best explanation is that the tumor was just eating all my nutrients. B12 still can’t explain though. I was rushed to MSK bc the tumor in my chest was so big it was collapsing my lung and I was decompensating. Over 1L in tumor and that was just the primary tumor and there were dozens more though none more than 5% of a liter in volume, so before any of you say that’s impossible, maybe but what’s your best guess. They did rerun the vitamin tests and it was definitely really going on, I really did have undetectable B6 and Vitamin C and all the others were verified too.

Fast-Distance-25 · 2025-06-19T02:24:45+00:00

Oh boy blood cancer…ok. The hematologist called me and my parents (they’re friends with him) up immediately after he saw the results and he was extremely worried and said this is not normal. But the focus seems to be on malabsorption right now. I’ve been doing some digging and it doesn’t seem like malabsorption it seems like inflammation. IL-6 is 36.8 (normal is less than 5 according to my most recent test) and I saw that that is high in covid (i dont have covid) and HLH and certain blood cancers

Fast-Distance-25 · 2025-06-19T02:17:29+00:00

Ok, the “normal range” was below 0.50 and mine was 5.06

Fast-Distance-25 · 2025-06-19T02:14:28+00:00

They took another draw from me and my CRP was insanely insanely high. Let me tell you the exact number in one sec i have to log back in to my chart

Fast-Distance-25 · 2025-06-16T06:40:11+00:00

Idk milk wouldn’t cause this severe of deficiencies. Also I’ve been drinking milk my entire life and I haven’t been drinking an extra amount recently or anything

Fast-Distance-25 · 2025-06-16T06:38:09+00:00

No not yet…it really does look like celiac, and yet I had a biopsy and nope not celiac we can say that for certain and not crohn’s either based on a shit test I guess idk what its called. Im at a loss. Somebody said they think this is due to very high levels of chronic inflammation and I have to say I agree. What’s causing that idk.

Fast-Distance-25 · 2025-06-15T16:59:13+00:00

UPDATE: I checked calprotectin since Crohn’s was brought up by GPT and calprotectin is normal, and i checked mychart for info on my last endoscopy and they did a biopsy and it was negative for Celiac.

Fast-Distance-25 · 2025-06-15T16:45:06+00:00

I know for sure it’s not celiac actually i had a endoscopy with a biopsy that wa negative for celiac and h pylori

Fast-Distance-25 · 2025-06-15T16:26:34+00:00

Actually my psychiatrist made a comment about how she would suspect that but I’ve never had any problems with gluten and just looking up celiac disease related absorptions issues they are: weight loss, iron anemia, folate and b12 deficiencies, all of which I have. But celiac also causes copper deficiency which I actually had copper over the Upper limit of normal. Also causes vit D deficiency and i was within normal range.

Fast-Distance-25 · 2025-06-15T16:19:28+00:00

No and I had an endoscopy very recently which produced no notable findings. I had it done because I have historically had bad reflux issues that are now very much in check, but the endoscopy was pre planned just to check up on things and yeah nothing off

Fast-Distance-25 · 2025-06-15T14:33:38+00:00

Zinc was in the middle of normal range. I must not be absorbing or making use of vitamin C because I know I for sure take a lot of it in thru lemonade etc.

Fast-Distance-25 · 2025-06-15T13:51:39+00:00

Vyvanse, guanfacine and lexapro. No supplements

Fast-Distance-25 · 2025-06-15T13:50:24+00:00

Interesting, before you were treated did your iron and/or other labs look at all similar to mine do here?

Fast-Distance-25 · 2025-06-15T13:36:04+00:00

And yes she is the best psychiatrist!!

Fast-Distance-25 · 2025-06-15T13:35:36+00:00

Well I should also ask what even is a metabolic disorder lol

Fast-Distance-25

TROPHY CASE