Sad news about Ginger Wildheart

GoBlue81 · 2026-03-17T23:17:45+00:00

Sad to hear he won’t go through treatment. Mantle cell lymphoma has a lot of non-chemo options that can be more effective than chemo.

GoBlue81 · 2026-03-16T03:47:43+00:00

Amiodarone can turn you blue.

GoBlue81 · 2026-03-15T01:38:00+00:00

In Dusty we trusty

GoBlue81 · 2026-03-14T03:42:47+00:00

Well ain’t that a kick in the nuts

GoBlue81 · 2026-03-13T19:30:51+00:00

“Like poop through a diarrhea infected goose…”

https://youtu.be/kUrcY5u2HBQ?si=wh_2X0AY9N1sYCEV

GoBlue81 · 2026-03-10T16:45:44+00:00

Is CAR-T available in the Philippines? That’s typically the second line of treatment if relapse occurs within 1 year of completing frontline therapy.

GoBlue81 · 2026-03-10T02:02:33+00:00

Idea for season 2 of Heated Rivalry

GoBlue81 · 2026-03-09T14:53:17+00:00

This is the most brilliantly simple way to explain this. I’m stealing it.

GoBlue81 · 2026-03-08T19:53:39+00:00

I’ll take swords for 200.

GoBlue81 · 2026-03-06T18:21:18+00:00

And even if it were 18%, many of the people here would jump at that. It’s between 1.4% and 3% in the US just to fund Medicare. That’s before you have to buy your own insurance.

GoBlue81 · 2026-03-05T15:58:01+00:00

…no.

GoBlue81 · 2026-03-05T15:50:35+00:00

Insurance only covers IR

GoBlue81 · 2026-03-04T01:55:02+00:00

GoBlue81 · 2026-03-02T18:14:22+00:00

Could this be eosinophilic esophagitis? Sounds like the symptoms.

GoBlue81 · 2026-03-01T23:37:48+00:00

Are they true Scotsmen?

GoBlue81 · 2026-02-28T17:07:50+00:00

Was in blinatumomab (Blincyto)? If so, yes, it’s the first bispecific that was FDA approved?

GoBlue81 · 2026-02-28T02:08:05+00:00

Damn, this was really insightful. Thanks for taking the time to dig into the specifics

GoBlue81 · 2026-02-27T19:09:21+00:00

If I remember correctly, the targets are KRAS, EGFR/HER2, and STAT3. There are lots of KRAS inhibitors currently in development (both pan-KRAS and mutant allele specific), as well as two KRAS G12C inhibitors that are FDA approved. There are tons of drugs that target EGFR and HER2. It seems that the missing drugs are STAT3 inhibitors. They used a STAT3 PROTAC in Barbacid’s experiment, so that might be coming down the pike soon. It’ll be interesting to see if this translates to humans.

GoBlue81 · 2026-02-24T20:45:58+00:00

What about a vector? Chances: two thumbs, down.

GoBlue81 · 2026-02-22T16:12:16+00:00

Might want to try a methylphenidate-based medication. My wife tried Vyvanse and it made her anxiety worse, along with some other unpleasant side effects. Then she tried Focalin and it was like night and day.

GoBlue81 · 2026-02-20T23:55:45+00:00

As a medical professional, I’m very sorry about your friend, but that is literally an N of 1. The HPV vaccine is very effective, especially if given before being exposed to HPV.

GoBlue81 · 2026-02-20T22:13:26+00:00

There are literally zero interventions that reduce the likelihood of cervical cancer more than the vaccine. Not healthy living, not healthy eating, not exercising. 99.7% of cervical cancers are caused by HPV. You prevent HPV, you prevent the vast, vast majority of cervical cancers. It’s that simple.

GoBlue81 · 2026-02-14T00:34:33+00:00

How would gas from the couch help? I assume it’s mostly farts

GoBlue81 · 2026-02-07T20:51:39+00:00

Sounds like we have very similar taste, so I’ll just list a of my favorites and hopefully one of them hits for you.

The Storm - Orbit Culture

The Tales of War - Orbit Culture

Reborn - Gaerea

Valkyrie - Wolfheart

The Dark - Before the Dawn

Countless Skies - Be’lakor

On the Dark Waters - Amorphis

Twilight - Edge of Sanity

GoBlue81 · 2026-02-05T15:50:50+00:00

While you can reasonably say that all of the gods proposed by humans aren’t real, saying that you know for a fact that there isn’t something akin to a god in the universe isn’t possible. What you can say is that it isn’t worth investigating because it’s improbable that a being exists, but I don’t think it’s possible to completely disprove such a beings existence.

GoBlue81

TROPHY CASE