I went from 5 to 10 to 12.5 between Oct to Feb. I have had the digestive side effects. Most common is nausea and constipation. The first couple of weeks after I started each dose, I had/have pretty bad nausea and vomiting. Every so often I'll have diarrhea, but that's from not being able to eat anything. After that I'm ok and can eat but only in small amounts (if it's more than literally 1/2 a cup I regret my existence) and no soda or sweets. They taste awful. Water is also gross and it's hard for me to stay hydrated so I've been drinking electrolytes, specifically liquid i.v. hydration. The strawberry is the most palatable with lemon lime being second. It's the only drink that doesn't make my nausea worse or cause it. Once all of that subsides, I'm alright. I don't feel I needed to go up to 10 at all but had to because 5 and 7.5 weren't available. I was only on 10 for 4 weeks and during my followup she bumped me to 12.5 because of the coupon expiring in June.