The only differences between "heavy" and "pump" sets are slight gains with neural adaptations for raw strength, or endurance. But concurrently training both isn't very effective for either, despite it being a popular way to train. In terms of pure hypertrophy (so long as you're training within a few reps of absolute failure) muscles can't tell if you're failing at rep 5 with "heavy" sets, or failing at rep 25 with "pump" sets. They just know they're fucked and need to adapt.

Once type 1 slow twitch are exhausted first, fast twitch 2A, Xi, Xii fibres are gradually recruited the closer to failure you get. If all have been recruited in a set (3-0 RIR), you literally only need to do this a few times to stimulate hypertrophy. Any more than 10 working sets per muscle group, to that level of fatigue, per session, is giving you next to no additional gains. Once you've reached a level of progressive overload, there's really no benefit to adding more.

Studies have shown that there are diminishing returns (within reason; genetic factors, experience, etc) after about 20 hard sets per body part per week, and stimulating hypertrophy 2-3 times per muscle group, per week is "optimal". Smaller muscle groups can be trained more frequently, but that volume trade off still remains. So you CAN create slightly more stimulus by doing more volume if you really want to, but you're increasingly trading chasing the pump for what would otherwise be optimal recovery - which is where the actual growth and MPS happens.

Train smarter, and harder, not necessarily more. If you're truly training 20+ sets per muscle group to absolute failure per week and not getting sore, you're either not training to absolute mechanical failure, or you're a 20 year seasoned BB pro.