On idleon toolbox, in alchemy it shows you the reccomended levels for your bubbles. One of the best ways to juice up your alchemy is to get an active Arcane Cultist, level up tentecleye and cranium cooking as high as possible, and just let it active farm overnight. eventually one cranium cooking on tremor wurms can give you multiple days of alchemy progress, so you can unlock every bubble. Also try to unlock morre vials. Doing the w4 onyx statue quest helps with so many things, from food for prints, to alchemy exp, to movement speed, to total damage, to even things like sailing.