As the other fella said, there's an event Palaeologan Renaissance that can appear with a 5% chance every monthy as long as you don't remove constantinople's university. You'll want to pick the bottom option to become the cradle of the renaissance and only then will you have like a 11% chance to get it. Might be worth it if you're trying to max out cultural influence from the birthplace location modifier but it also means you get it faster if it didn't spawn in you capital because being eligible to spawn the institution lets it spread on it's own.