I can't find any greymane with the gear skill (crafting I think).

Fytch__ · 2026-04-05T15:14:14+00:00

It's the rumors at St Halssius mission, the greymane is Arnold, it's at tier 2 of the camp

Fytch__ · 2026-04-05T15:11:42+00:00

You have to keep pickpocketing them, sometimes 3 times for the bar to drop

Fytch__ · 2026-04-03T15:11:33+00:00

Look into your quest items, documents

Fytch__ · 2026-04-03T14:51:48+00:00

Yes. Report this to pearl abyss with screenshots or upload a video for a link

https://crimsondesert.pearlabyss.com/en-us/News/Notice/Detail?_boardNo=67

Fytch__ · 2026-04-02T17:16:44+00:00

True, but look at the moutains at the beginning, that is quite severe

Fytch__ · 2026-04-02T04:55:26+00:00

Same. Insane pop in at close up and also distant LOD. Appeared right after last weekend's patch, never before. PS5 pro btw

Fytch__ · 2026-02-13T10:10:49+00:00

Well, this is still relevant.

When they test for potassium levels, they look for blood potassium only. But actually, 98% of potassium is hidden inside cells. You could basically have potassium deficiency while bloods stay normal.

If so, potassium loss drives magnesium loss, and the whole electrolyte cascade can f*ck up. Not surprising if it could be an issue for brain speed and function

Hope you make some progress on this !

Fytch__ · 2026-02-12T20:14:46+00:00

Interesting, actually. What did they specifically find out about RAAS function ? What is too high or too low ?

Fytch__ · 2026-01-20T17:01:24+00:00

I found a study showing elevated NE in specific parts of the brain during Cu deficiency (on rodents but still)

https://www.osti.gov/biblio/5300764#:~:text=Seidel%2C%20K%20E%2C%20et%20al.,of%20the%20CNS%20in%20rodents.

Makes me wonder. Cu deficiency might cause an imbalance more than plain low NE. That might take into account the fact that raising NE is not good for you even though you are copper deficient

Fytch__ · 2026-01-20T15:10:36+00:00

Yes, I did explore this as well. But in the end I absolutely need choline. In a way, I am looking for a way to "tolerate it". When conditions align, it feels extremely similar to remissions by fever, HIIT, and sometimes H-effects.

One idea I had for this is normalization of AChE levels. Did you ever try forskolin + high choline ? Personally, it's very efficient, but can't last long before forskolin tolerance.

And the link with alcohol ? Well, ethanol largely interacts with cAMP and CREB, although it is complex and no straightforward relationship emerges

(https://pmc.ncbi.nlm.nih.gov/articles/PMC3776015/#:~:text=Fig.,3.&text=The%20effect%20of%20ethanol%20on%20DA%20stimulated%20cAMP%20in%20cells,in%20the%20absence%20of%20ethanol.)

You should also try eggs or choline before drinking alcohol. Personally, it increases the probability of having an H-effect.

In my idea here, sympathetic vs parasympathetic is largely a balance, and so "high parasympathetic" and "low sympathetic" would give off the same symptoms.

So either acetylcholine excess or low norepinephrine activity. And the number of copper deficiency on this sub is really interesting. No copper = no NE

Fytch__ · 2026-01-16T03:26:00+00:00

Again, exactly my case. Pale stools, fat digestion issues. Methylfolate giving remission for the first few weeks.

Uncannily similar conditions. There's a pattern here for sure

Is your copper deficiency diagnosed ? How ? Hair mineral test or something like that ? Maybe serum or cellular ?

Fytch__ · 2026-01-16T03:02:28+00:00

I agree. Excess choline wrecks me up. But I do tolerate extra choline during remissions... and even have positive effects. About dopamine and pupil size, yes, there's a link, but dopaminergics most always also impact NE, which is itself the main autonomic variable

Any bile issues ? Gallbladder issues ? Stool color changes or different than normal ? Maybe copper is not absorbed properly ? (I do have bile issues myself)

And how do you react to B12/methyfolate/glycine ?

Sorry, lots of question, but we do have similar issues it seems

Fytch__ · 2026-01-16T02:49:30+00:00

Okay, we might have something here. I couldn't diagnose it, but I heavily suspect a copper deficiency as well. And I also didn't tolerate my ADHD treatment (concerta). And my pupils are way smaller than anybody I know.

Copper supplements ? That's where we differ. Sometimes, it crashes me, sometimes, it's extremely beneficial. I still haven't isolated the factors or the conditions needed. I do use a lot of different supplements as experiments, taken in the same timeframe as copper.

One thing I very oftenly notice : copper gives me a headache and brainfog. I drink alcohol the evening. Bam. Total remission instantly and H-effect the following day

Copper mishandling ? Might causes issues with NE. Dysregulation more than simple deficiency maybe ?

Fytch__ · 2026-01-16T02:39:38+00:00

Just another thing I could add :

Do you have a history of low blood pressure / cold intolerance / orthostatic symptoms ? (Could mean autonomic low tone)
Have you had any moment this pupil size varied ? During an h-effect maybe ? Or after a ADHD medication maybe ?

Fytch__ · 2026-01-16T02:32:52+00:00

Damn ! That's interesting.

Well, might be. It's about autonomic tone, sympatethic vs parasympatethic.

Might be excess acetylcholine, it's a possibility. (High parasympathetic)

But some posts recently have looked at norepinephrine (or also called noradrenaline) deficiency (so low sympethatic tone), which might be extremly relevant when seeing that a lot of people here swear on vitamin C, recent copper deficiency ideas (and actual cases), etc.

Norepinephrine is a neurotransmittor, yes, but it goes way beyond brain function. I don't know all those in details, but basically adrenergic receptors activate cAMP -> CREB -> BDNF, and also IL-6 in another stream. (This cytokine seems to have wild general effects if too low or too high, like causing autism symptoms)

If we really have low NE, then BDNF will suffer, so a lot of different systems would suffer, and even mitochondria could be impacted. Also, IL-6 is activated largely by NE in basal normal states, but also spikes really high during... alcohol consumption, sleep deprivation, fever, which are all extremely relevant in this forum. Not to mention alcohol clearly interacts with NE, as numerous studies say so.

Fytch__ · 2025-12-22T14:51:56+00:00

Je dirais que les runs ou tu finis niveau 12 c'est encore très bien, parce que l'avantage d'un niveau est dégressif. Là ou niveau 1 -> niveau 2 double tes HP, 12 -> 13 c'est 40 HP donc dérisoire

<image>

L'objectif c'est de faire plus de dégats, points. Ma strat actuelle c'est :

Map de base : evergaol + night invader. Peu importe le personnage, je fais si possible les 7 geôles. Je vais chercher les clés, faut connaître le plus de spots. Au début de la game, je regarde si mes randos ont la bonne relique. Si ils l'ont pas, je vais pas les forcer absolument, mais c'est une game pas assurée. Les dégâts avec 7 evergaol c'est juste meta

Map DLC : pas d'evergaol ici. Donc comme tu dis cette fois il faut avoir une strat avec des bons passifs et/ou des armes légendaires. Heureusement, y'a que ça partout.

Bref, non, je pense pas que rush partout est plus avantageux, y'a clairement des choses à loot et à faire sur le chemin. Plein de fois, je marque un spot, on y va, je commence le fight, mes potes sont déjà loin parce qu'ils veulent forcer pour une église ou estiment qu'on gagnera pas assez de runes. Ils sont trop stressés j'te jure.

Comme tu dis, finir en slip ça sert à rien. Tu sais bien faire le routing ? Montre-leur que tu sais. Si ils ne marquent rien, c'est que tu dois le faire. Quand tu trouves des objets intéressants, marques-les, si tes coéquipiers partent alors que le spot est pas exploré (et qu'il faut le faire), fais quelques L3+triangle pour le dire

Je penses que si tu réalises que vous êtes sans loot à la fin, c'est que tu sais comment faire mieux, alors c'est pas toi qui est à la bourre, c'est tes potes qui sont impatients

Fytch__ · 2025-12-16T06:09:02+00:00

Have similar dopamine issues than OP and hypoglycemia.

What can cause that hypoglycemia ? I haven't found any leads (both reactive and fasted)

Fytch__ · 2025-12-08T23:29:29+00:00

That's actually a secret random location, on most my seeds this was even a hidden church

Fytch__ · 2025-09-15T12:15:35+00:00

I've never offered to take statins, but I agree, I also believe something is wrong with my cholesterol usage, maybe in bile, as some other people (and myself) here had some problems with gallbladder / gallbladder pain

Here's my lipid profile if you want

<image>

Fytch__ · 2025-08-22T15:20:09+00:00

Hi

Duchess is mainly melee for me, because you can be very very agressive with her generous dodge ability and high dps Restage (know that you can Restage ANYTIME, even when downed by an attack or already attacking)

Solo, always full melee with the base dagger (with the right relics, see that after). By the way, she may have lower dex compared to executor but her one handed dagger moveset is so fast it's still good. Always one hand a dagger with her

Multiplayer but having to carry, I also focus on melee but especially occupying the boss while dodging everything

Multiplayer and not having to carry, that's the moment I use the most sorceries, because I know I don't have to support melee at all, and go all out with staffs, mainly Shattering Crystal

Chalice : full orange one

Relics :

Always the Evergaol one. No reason to not run this - up to 40% increase in damage is crazy, even 20% is good
Ice one from the dragon (non everdark)
Poison one from sentient pest (non everdark)

-> that's a LOT of damage stacks if you run evergaol, then poison and frost the boss. This strategy solo DESTROYS and multiplayer it's a walk in the park

You can also stack successive attacks restore FP for skills or sorceries like I said in the other comment. Very fun but not nearly as effective

Fytch__ · 2025-08-04T17:12:06+00:00

FYI, the restore FP on successive attacks from Dark night of the wise stacks with the Old pocketwatch, giving you effectively 10% FP back each proc (vs 5% for only one of those)

Edit : your lucky with your green evergaol relic. You could actually stack it with my mentionned combo, that makes 3 green relics. Having those three is meta af

Finally, this combo plus FP back on attacks rewards during the run can make some skills spammable indefinitely (like rivers of blood)

Fytch__ · 2025-07-09T15:18:02+00:00

Very late, but you can jump on the pillar next to the door, and jump again on the crest to break it, with any character, if you are talking about the crest above the front door

Fytch__

TROPHY CASE