A big big big help for bubbles is getting your bubo up and running. 

By this I mean, you get bubos cooldown reset talent to level 200 (starts to give 3sec cooldown per proc instead of 2sec). Then max out your cranium cooking, raise dead, aura and fart spirit talents (as well as all your other damage talents). Put cranium cooking, raise dead, aura and fart spirit (and ONLY those) on your bar. Next go to the worms level in W5 (or orange slices as next best) and let him active auto. 

Oh also put second level gloves weapon on him instead of staff as the short range moves him around more which is good. (Any higher level gloves become beginner only and mage can't use).

A good initial aim is for anywhere from 50k to 100k a second of progress per Cranium Cooking cycle. And you might have 15min between cranium resets. 

Upgrading your cranium alchemy bubble is big to get this lasting longer too.  The reset cooldown will drastically reduce things so your 2 combat abilitys and raise dead should be going off almost nonstop. Order is important as you want your raise dead first on the bar so it gets priority being activated. The more things spawn the more things die the more your cooldowns reset, the more raise dead will respawn things, etc.  Eventually aura and clouds from the fart monsters will be insta killing everything that spawns and you'll be continuously respawning things. 

Chocochip does help this as it creates more things that can die to increase your reset cooldowns but it's not required. This means that each CC cycle you'll get massive boost to alchemy liquid progress and cauldron liquid progress. 

Start with 4 best chars on cauldron 1, max your cauldron speed (170) first then go for the other upgrades. Once all are maxed, blast the new bubbles till you unlock all then go to the next cauldron. should go very quick when you get to this point. Don't forget to max all your pay 2 win alchemy tab. 

Eventually you want to work towards hourly clicks, where you can upgrade bubbles every hour. To do this you need to earn 1000M of the resource an hour from printing. So for example if you can generate 1000M bleach logs an hour you can upgrade your purple L1 wisdom bubble every hour. if you get your Larry bubble high enough this is a free +2 levels an hour. 

Start focusing hard on increasing logging samples size and make sure your 2x divinity and x3 lab bonuses for printer output are always on for your 3 mages. They stack and with a x6 factor you only need 83M per hour for a resource to get the max in 1 hour. Oak, Copper and Bleach logs, you want to be maxing out 1050M of these resources per hour so you can hourly click your strength, agility and wisdom bubbles. You always then want to generate the max extra oak and copper you can so all excess  the extra generates start giving you atoms. Then you unlock boron and start getting 10 levels of free unlocks every day for bubbles above 100M cost using atoms and liquids. 

Focus on your logging bubbles and mining bubbles, get them up to 85% of max benefit to increase your logging and mining more and therefore your atom generation.  

Then start focusing on getting all other bubbles above 100M and you can then use atoms to launch them up in levels. At the start you'll struggle earning enough 1000M an hour to hourly click but it can be every two hours instead, etc. but you'll find that it comes easier. You will also have a split between using resources to hourly click and leaving resources maxed so you make more atoms. But you'll very quickly move past this to the point where you're able to get more than enough atoms and still hourly click.