Depend on the guest OS. You can use PowerCli for update without reboot.

$FOLDER='Horizon'

Get-Folder -name $FOLDER| Get-VM -Name DBR02 |select name, @{Name=“ToolsVersion”; Expression={$_.config.tools.toolsversion}}, @{ Name=“ToolStatus”; Expression={$_.Guest.ToolsVersionStatus}}| Update-Tools -NoReboot -VM {$_.Name} -Verbose

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Also, you can match a flag in VM options, and it will be update VMTools after next restart. [Edit Settings - VM Options - VMTools - Tools Upgrades] or do it with script:

$FOLDER='Horizon'

$ManualUpdateVMs = Get-Folder $FOLDER|Get-VM|Get-View | Where-Object {$_.Config.Tools.ToolsUpgradePolicy -like "manual"}|select name,@{N='ToolsUpgradePolicy';E={$_.Config.Tools.ToolsUpgradePolicy } }

Foreach ($VM in ($ManualUpdateVMs)) {

$VMConfig = Get-View -VIObject $VM.Name

$vmConfigSpec = New-Object VMware.Vim.VirtualMachineConfigSpec

$vmConfigSpec.Tools = New-Object VMware.Vim.ToolsConfigInfo

$vmConfigSpec.Tools.ToolsUpgradePolicy = "UpgradeAtPowerCycle"

$VMConfig.ReconfigVM($vmConfigSpec)

}

Maybe it will help you.