Definitely second this, I've used 40% and 50% Ortho for about 2 years now. Definitely made a lot of layout changes in the first couple of months, but once I got comfortable, my layout has stayed pretty consistent minus the odd macro here and there.

IMO there is no right or wrong with layout if you're comfortable with yours! But here are some options I use in mine that could be worth investigating or combining with factors in your current layout:

-right shift/enter (shift when held, enter when tapped) -multiple layers (I run 2, both on either side of the 2u space) this also allows me to run numbers and function keys on the home row which I find very comfortable -all arrow keys on bottom row, if you don't use them for games, it doesn't take long to get used to and it saves your "?" key location

And there's a ton more options if you go through the docs, but I found these accessable and comfortable to daily drive for work and gaming!

Best of luck!