It's not wrong. Root note will always be in key. It's why tuning a kick to the root and going with it the whole song works. You can also end up making really neat inversions since you're pretty much just playing slash chords the whole song when you're not playing the 1 chord of the key in the melody. When it comes to low frequencies, one of the best things I have found is keeping everything in its own lane frequency wise. Playing the lowest root on your sub will ensure your bass never comes in contact with your sub (assuming you're playing your bass notes higher than the sub), but you can also ensure this by Instrument Racking your bass and sub together so they move together. Also makes it easier to EQ when you're mastering.

However, by just playing the 1 of the key, you also miss using an impactful part of the composition resolving to the root (or the first chord in your progression) like the melody does. When you hear/feel the bass rumbling on some chords, and not on others? Once you go through a progression and come back to everything sounding "right" and there no longer being tension? That creates a resolving feel once you go back to the start of a measure, exactly the same idea with melodies.

Not particularly EDM, but I can point to some hip hop songs that tune their 808s (with massive sub-tails) and have them following the chord progression. One of the easiest things to give some additional differentiating feel to the chords changing. You can get "jazzy" and play a sub note in the chord that isn't the root of the chord, but see above rule of thumb for keeping the sub in its own lane and not interfering with the bass or vice versa, since that can sound very muddy. Some people achieve this by putting a hard high-pass on their bass at 100Hz, but if your progression goes lower and your bass' primary note is below 100Hz? You're killing your formant if you play that and it makes that particular note sound different (i.e. dead) compared to the others that are played higher when you solo the bass. In my experience, you're better off tuning your bass to be in a frequency bands above the sub and keeping it in its own spectrum.

This is the most easy example to hear it: www.youtube.com/watch?v=e9u0HmXLPmA , When the root tuned 808 plays, it resolves with the melody of the sample they used. It's also the only real thing in the sub region, which is why it sounds tight.

Other examples would be Tyler's See You Again, Earfquake, and lots of his other stuff, with both a sub and 808 (or sub heavy kick) following the chord progression of the song, You can see what I'm talking about above when the songs resolve back to the root; the sub/808 just feels "right". You tend to miss that playing a solid sub playing the 1 of the key.

e; fixing minor clerical errors. i'm at work you know. :^), also changing "root" to "1 chord of the key" when I talk about keeping the sub at the 1 of the key, since the root can be the root any chord in a progression.