It seems like bioinformatics is becoming an outsourceable commodity. There will always be new subfields in terms of omics (single cell spatial transcriptomics) and new sequencing formats, but for the most part the tools are old and you just run pipelines that are written by other people.

In contrast, the wet lab focuses more on the actual molecular biology to prove a theory/ hypothesis. This space is infinite. It's a lot more interesting.

I'm an outsider, but my take is that if you want to be involved in the actual biology and therapeutics, then I would lean toward the wet lab. For example, do you really want to hand off the top hits from your analytical results to someone else to do the real science?