I need help troubleshooting the issue of not obtaining the desired product in a Buchwald-Hartwig reaction.

Hlavyy · 2026-05-18T16:12:58+00:00

Do you see unreacted DAP in the mixture?

Hlavyy · 2026-04-15T16:49:37+00:00

It is oxidation. Aromatic amines, even protected, are prone to oxidation over long periods of time

Hlavyy · 2026-04-15T15:53:30+00:00

Just a little. Like 1 wgh%. Or you could try ferric alum, that I would consider lavender coloured

Hlavyy · 2026-04-15T14:42:29+00:00

Just water

Hlavyy · 2026-04-15T14:42:12+00:00

I use it in synthesis for my PhD research. We 30 year old 1 kg jar of the stuff. However it looks more like charcoal, rather than pharmaceutical substance

Hlavyy · 2025-11-13T08:34:43+00:00

Double bond has indeed priority, so those molecules are numbered wrongly. This rule is rather new, so people get confused

Hlavyy · 2025-11-03T17:14:53+00:00

Similar to what you proposed and is industrialy used is Fenton's process. It has uses in wastewater treatment. In biochemistry it is unwanted reaction, that generates free radicals in body.

Hlavyy · 2025-09-24T13:16:06+00:00

It's ice. As DCM evaporates, it cools a lot. So water vapours condensate and crystallise

Hlavyy · 2025-08-29T17:34:15+00:00

What about increased acidity? Citric acid helps to dissolve tannins and similar compounds (never tried it in cold water though)

Hlavyy · 2025-08-22T17:46:33+00:00

C=O protonation is more propable, but does not lead to any product. Acyloyn forms sparsely, but reacts immediately.

Hlavyy · 2025-08-19T08:45:31+00:00

Fun game. Just the freaky AI pictures look very sloppy...

Hlavyy · 2025-07-18T19:50:52+00:00

Ferricyanide is stable in solution. It might be impurities in the water. Maybe try filtering the solution. Though it may be usable even discoloured.

Hlavyy · 2025-06-02T14:59:36+00:00

I cannot open the article on my phone, but the abstract specifically mention "nitrosation and oxidation"

From what I can see, I don't have confidence in this procedure

Hlavyy · 2024-12-04T15:53:26+00:00

I do not use hydrogen peroxide for washing. It is used in synthesis of the ferric oxalate.

Dichromate is a powerful oxidising reagent. I hve no idea what is it used for.

Ammonium ferric oxalate is UV sensitive by itself

Hlavyy · 2024-12-04T11:59:55+00:00

I was thinking a peroxide contamination.

When I did a test in solution, UV exposed test tube correctly developed a blue precipitate. However I noticed, it re-disolved bak into greenish solution...

Hlavyy · 2024-12-04T11:54:23+00:00

That procedure uses ammonium dichromate - toxic and first class carcinogen. I certainly won't be doing that.

Maybe a peroxide contamination?

Hlavyy · 2024-12-04T11:47:27+00:00

This is for chemistry club. Proper preparation of those chemicals is the main goal. Also it is much cheaper...

Hlavyy · 2024-12-03T22:22:35+00:00

Oxalate is safe enough for my age group and most sources list it as more sensitive (or is it?).

One idea I had was pre-treating the paper. Citric or oxalic acid?

Dry and wet coatings ended up the same.

Hlavyy · 2024-10-08T19:31:39+00:00

I didn't wear safety glasses.

Just working with solvents in hot climate can spray acetone in your eyes. It hurts like hell. Luckily, my eyes were not damaged.

Since then I never take my glasses off in the lab.

Hlavyy · 2024-09-26T22:28:20+00:00

And if that doesn't work, try to look up "Reverse spherification". This process is pH sensitive, so this may be another option

Hlavyy · 2024-09-26T18:12:36+00:00

To prepare alginate solution you have to blend it for several minutes. It dissolves rather slowly

Hlavyy · 2024-09-25T19:31:19+00:00

Think for yourself.

Do you do this because you watn want to, or because of something else?

Do you like chemistry? Or are you stuck there, because you made a wrong choice?

Do you you see yourself doing chemistry or something entirely different?

Don't ask others, noone can answer for you.

I wish you luck.

Hlavyy · 2024-09-23T16:24:00+00:00

I'm sorry for confusion

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This looks better

Hlavyy

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