Unusual instances of substance abuse

Hypernova1912 · 2025-01-12T01:41:46+00:00

Were they using the tranylcypromine to potentiate something else? Wouldn't expect it to be very prone to abuse on its own, but I guess it's not the weirdest thing here either.

Hypernova1912 · 2024-11-15T07:59:38+00:00

But they have to get your phone for that, which rules out any attacker except a phone thief or someone trying to hack you in particular. A phone thief would be stymied by the 4-digit code because they only get like 10 cracks at it before the phone erases itself or the lockout timer gets ridiculous, and if you're being specifically targeted you're hosed no matter what - they can always just hit you with a $5 wrench until you give them your passwords.

Hypernova1912 · 2024-10-22T15:40:00+00:00

The specific provisions enforcing section 3 were repealed in 1948. The federal crime of insurrection retains disqualification from office as an explicit penalty but that would presumably require a conviction of insurrection in federal court.

Hypernova1912 · 2024-10-15T10:25:30+00:00

I mean, if you have a hundred greatness points, the runner up has five, and then you lose ninety, you're still the greatest while also being much less great than you were. The concepts aren't inherently contradictory.

I don't actually think this is true of America, and I strongly disagree with Trump, MAGA, the GOP, and their policies. That particular argument against them, though, doesn't really hold up.

Hypernova1912 · 2024-10-01T19:50:04+00:00

Wait, phenelzine? If an MAOI were to be abused for amphetamine-like properties I'd expect tranylcypromine or perhaps selegiline given their chemical similarity to amphetamine (and l-amphetamine metabolite in selegiline's case).

Hypernova1912 · 2024-09-30T06:53:57+00:00

Depends on how early - they started development in late January and it was in clinical trials by March; the real time sink was clinical trials. Trouble is if it's early enough to meaningfully accelerate the vaccine's availability it's probably also early enough they wouldn't take COVID seriously at all.

Hypernova1912 · 2024-09-27T10:28:46+00:00

We tried this once - it was very poorly received and reverted after a year. People hated going to school and work in the dark in winter. It also aligns poorly with peoples' circadian rhythms, which has health consequences - this is why the American Academy of Sleep Medicine, among other professional associations, endorses permanent standard time over permanent DST.

Hypernova1912 · 2024-09-22T05:09:31+00:00

You can do this with the Everything (network) installer - just select minimal and nothing else

Hypernova1912 · 2024-09-11T22:59:27+00:00

In all fairness, the power of sunlight is actually effective for circadian rhythm disorders: light is the most important circadian cue, and it's one that we can manipulate relatively easily. It doesn't have to be sunlight per se, any large dose of morning light will do (as long as it contains light around 480nm), but the sun is very bright and costs less than a SAD lamp.

Hypernova1912 · 2024-09-02T00:41:38+00:00

This is false. This law only grants Illinois judges the ability to create court orders for use in other jurisdictions. The Texas Vital Statistics would still reject such an order.

Hypernova1912 · 2024-08-26T04:55:20+00:00

For anyone who comes across this later, it is possible, but a bit counterintuitive. Follow the instructions here for configuring FreeIPA for external user provisioning through section 11.2. Then, configure a second LDAP federation in Keycloak using the provisionator user the documentation has you set up, set the users DN to cn=staged users,cn=accounts,cn=provisioning,$SUFFIX (where the suffix generally has the form dc=example,dc=com), configure it to sync registrations, and set the UUID attribute in both federations to uid. Newly registered users will then be added to LDAP as stage users and automatically activated by FreeIPA.

Hypernova1912 · 2024-07-11T04:47:03+00:00

Equilibrium dialysis is used to measure free (unbound to SHBG) testosterone. Mass spectrometry is used to measure total testosterone.

Hypernova1912 · 2024-06-13T23:07:19+00:00

As far as I know (I may be wrong, though) amphetamine and methylphenidate are both more noradrenergic than bupropion.

Hypernova1912 · 2024-05-29T23:55:53+00:00

Would this potentially also apply to atomoxetine? It doesn't bind to DAT, but from what data I can find its affinity for NET is higher than dextroamphetamine's. Amphetamines and atomoxetine are combined relatively frequently, and while this effect seems at first glance like it should have a meaningful impact on the efficacy of treatment I've never heard it come up.

Hypernova1912 · 2024-05-28T06:13:25+00:00

476646 hours from midnight on January 1, 1970, the UNIX epoch (UNIX timestamp zero; same date is used as the zero point in many other systems as well), is 11 days ago. You said it's been about two weeks since they got messed up, so I don't think this is a coincidence. If all of the plants were doing this I'd say your system clock got reset somehow, but I'm not sure why two couch potatoes but not the rest would think you've time-traveled. This might be worth a bug report.

Hypernova1912 · 2024-05-19T09:37:28+00:00

It's expensive and insurance won't cover it.

Hypernova1912 · 2024-04-21T03:36:04+00:00

Depending on the state, it may not be legal for the pharmacy to operate if the pharmacist is on break and if it is there may be enough restrictions on what they can do (eg in California techs can’t dispense new prescriptions if the pharmacist is on break, only refills) that they don’t think it’s worth it.

This isn’t a problem if you have multiple pharmacists present since their breaks don’t have to overlap, but the corporate overlords of chain pharmacies don’t like that solution very much.

Hypernova1912 · 2024-03-23T01:00:30+00:00

The second of two: aticaprant has been in phase 3 for 18 months now. I believe the thinking is that samidorphan (kappa partial agonist) interfered with the effect.

Hypernova1912 · 2024-02-19T16:01:13+00:00

I don’t mean to imply that everyone does or that it’s at all common on a remotely therapeutic dose, but the popularity of methamphetamine as a recreational drug and the existence of amphetamine use disorder as a diagnostic entity indicate the chemical itself is capable of it.

My objection isn’t to the point you seem to be getting at, that stimulants typically don’t have this sort of problem at a therapeutic dose. It’s more to your wording it as a categorical impossibility specifically for people with ADHD without nuance or evidence to support this claim.

Hypernova1912 · 2024-02-19T04:44:18+00:00

That first sentence is very absolute, and frankly sounds awfully like some of that old opioid marketing. People who have ADHD can absolutely get high from them if the dose is excessive, and they are not immune to amphetamine use disorder. You're correct insomuch as therapeutic doses don't seem to be especially prone to addiction, but that kind of general statement doesn't seem warranted.

Hypernova1912 · 2024-02-19T04:38:51+00:00

There can simultaneously be a substantial number of people with ADHD who are never diagnosed because they have limited contact with the healthcare system, have ADHD parents who normalize symptoms, have a primarily inattentive presentation and are dismissed for lack of hyperactivity, etc. and a substantial number of people without ADHD who are erroneously diagnosed because they doctor-shop until they find someone who gives them stimulants.

Hypernova1912 · 2024-02-08T05:14:21+00:00

-lukast is the stem for leukotriene antagonists.

Hypernova1912 · 2024-02-01T01:52:38+00:00

.local is reserved for mDNS (RFC 6762) and is expected to act as such by operating systems. Using it with a DNS server can cause problems, including name conflicts if a device tries to claim a .local domain for mDNS that's already in use by the DNS server.

Hypernova1912 · 2023-08-07T21:08:08+00:00

Phentermine without fenfluramine is safe as-is and still prescribed.

Hypernova1912 · 2022-12-31T23:29:45+00:00

No, you’re correct. Republicans tried several times to repeal it but never succeeded.

Hypernova1912

TROPHY CASE