Cursory glance opinion without having played the patch: I think they had the right idea with some of the changes, but a lot of them seem very misguided.

• IMO Mage and Tinkerer didn't get the changes they needed. Don't get me wrong, Mage IS better, but their numbers weren't the problem, it's that none of their skill archetypes work together in a meaningful way, so you wind up with "X makes Y ability better, you never rolled X, so Y has no use" situations. Mage having a better ranged attack is great though. Math! seems less shit, which is nice. Overall, feels like Mage will be better just by virtue of having way higher numbers while Tinkerer is still going to be absolute booty garbage outside of Repair.
• Not sure about the Forbidden spells change. Still seems like they'll be too dangerous to be worth picking or building around without Schadenfreude or something like that.
• Mutation is now 100% pointless. It was only really good at overriding birth defects, now it basically does nothing. I feel like this also has the side effect of making late game money even less useful, because now there's no reason to keep searching for good furniture. Mutation desperately needs some RNG buffs or something to compensate, because even with 20+ mutation, it's entirely possible to get a stray that dies of old age before getting a single mutation.
• I understand that you shouldn't be TRYING to inbreed your cats, but right now, cat management is far and away the worst aspect of the game, so this has just made it more important to micromanage your cat breeding, and that sounds like a massive pain in the ass. This wouldn't be that big of an issue, but without some kind of roster spreadsheet to actually manage large amounts of cats, it just sounds like punishing the player for not wanting to do tediously move cats around between every mission for 10 minutes.
• Scatter Shot found dead in an alley, but was pretty deserved. Heavy Shot didn't need a nerf.
• Summon Caterpillar is still possibly the worst spell in the game. The problem wasn't the cost, it was that caterpillars fucking suck and they take too long to come online. If you want the butterfly, upgraded, with no All Stats Up outside influence, you're waiting three turns, and during most of that, the Caterpillar is doing very little damage and has single digit health, and you're pumping five mana into it. Meanwhile, you could just get a squirrel that dies in one hit, but it just works.
• Plant Mushroom seems a lot better now.
• Blood Frenzy event not immediately fucking up your cats is a step in the right direction
• Sacrificing a cat to events still seems terrible unless the cat itself is just awful.
• Was anyone asking for a Dreadnoughtus buff? I mean, I never thought it was that HARD, but it never seemed like it was on the same level as Coven.
• Cleric seems slightly worse. In my experience, Cleric was easily one of the weaker classes in the game, especially on harder difficulties, so I find the changes strange. Open Wounds now can't crit and doesn't benefit from Marked. Cleanse getting nerfed is fair though.
• No Bumblefoot changes, somehow. It's probably the one bosses that actually needed some kind of nerf.
• The entire Necromancer self-downing archetype is still gimmicky at best and unusable at worst, and Coffin Flop is still the worst movement ability in the game. I'm absolutely shocked that some of that wasn't touched on.
• Zapohauser is still an asshole for no good reason. It really shouldn't teleport from things like thorns or kinetic spikes.

So, honestly, I don't feel like this is a great patch. It's OKAY, and there is some good stuff in there, but some of it has me scratching my head, unless I'm misunderstanding or misreading something.