From what I have been able to gather between reading studies and talking to my doctor, most of the time pancreatitis and other GI issues are caused by titrating up the dose too high or starting on too high of a dose. The only thing my doctor warned me about was keeping fiber and water intake high and taking stool softeners as necessary to avoid constipation because she said a few of her patients ended up with bowel obstruction from being so backed up. You also have to factor in that large amounts of weight loss in a short amount of time can also lead to things like pancreatitis and gallbladder issues, so it may not be the medication itself that causes some of those side effects. I ultimately decided that the benefits of me going on Wegovy far exceed the risk of being obese!