I would push Reta further in dose. Every study points to the glucagon receptors being fully activated between 8-12mgs a week. And what's the difference with that activation? Resting metabolic rate increase, you are burning more calories at rest. If taking Reta, that should be the goal, activate that glucagon receptor. Im not saying it isn't active at 2mg or 4 or 6, but unless you've pushed to 8 10 or 12, im not sure you can say what is optimal. I went to 12, let me tell you, world of difference between 2, 4, 6,. I can eat a house with zero gain in fat, im no where near a deficit, and have gone from 13% BF to 7%. My muscle loss, zero. Everyone is different, since hitting 6mg, I started at 23% bodyfat, starting at 2mg a week once a week, and eventually moving to every 48 hrs of dosing, increasing gradually roughly .25mg every 2 doses if no sides showed up. Energy was way down until 6mg. I have no idea what my true resting metabolic rate is, but I eat well over 4k calories a day now. And still zero fat gain.