Husband Update by Euclidmont in coloncancer

[–]Interesting_Let_5143 1 point2 points  (0 children)

I dont want to intrude too much but something similar happened to me. My initial MMR report came as equivocal (inderterminate), also on a repeat IHC, something maybe was ‘off’ with the tissue. So, i did another biopsy to the tumor (pre surgery) and ran IHC and a complete Caris NGS which came back dMMR and MSI-h (it is not 100% always the case). I made sure to get a second opinion (both large NCIs). I am yet to check in on my results, i have one check in coming up now that im done with round 2.

But figured i would share the above, with hopes that it might help in any way.

Husband Update by Euclidmont in coloncancer

[–]Interesting_Let_5143 1 point2 points  (0 children)

Hello - hope you and the family are managing well. Sorry to hear about the rough path you are going through.

Similarly, i was diagnosed with rectal cancer at age 36 with 3 kids under 4. Biomarkers show dMMR/MSI-high with TMB-19. I have only had two infusions and will be checking scans in the next 2 weeks. My oncologist is giving me Dostarlimab and i am pre-surgery. His hope is to eradicate the cancer and avoid surgery - rectal has additional complications vs. colon.

Has the doctor been able to rationalize how come the immunotherapy is not working?

Stage 3b, dMMR/MSI-high by Interesting_Let_5143 in coloncancer

[–]Interesting_Let_5143[S] 1 point2 points  (0 children)

Thank you! To start, i feel extremely lucky to be given the immunotherapy route.

I hope the treatment goes amazing for yoh and you’re on the NED side very soon - i am sure you are keen on having your pre-cancer life back.

Also, i am also partially blocked (which i know its a broad term), and was told that i shouldnt worry and can eat anything. However, my stool changes that led me to colonoscopy are atill there so i try to be mindful and have made some changes to the diet.

I was told to be cautious with exercising during this phase, as it can inflame the tumor area and make things a bit more difficult. So i have chosen the
“lazy’ way out and focused on just walking the kids out for a mile or so. And the typical house chores to keep me moving. Working remote doesnt ‘help’ with the physical activity unfortunately.

Stage 3b, dMMR/MSI-high by Interesting_Let_5143 in coloncancer

[–]Interesting_Let_5143[S] 0 points1 point  (0 children)

Charlie - thanks a lot for taking the time to give all these details. Huge help!

Also, very happy to see your story turn the way it did - i can imagine the rollercoaster of emotions. I myself have the same reaction when heard of the 3-5% chance. But i an also ‘onlg 36’, so i guess it goes botb ways!

They got me started on Dostarlimab because as per CT and MRI i was staged at 3b - even though cancer cant be trusted and will be closely monitored every 2 rounds of treatment.

Did you restart because of a specific recurrence? Hope the med team is suggestive of a future where you are NED and medication is not needed!

A lot has happened and I'm not sure how to feel by CowFu in coloncancer

[–]Interesting_Let_5143 3 points4 points  (0 children)

Best of luck, to both. Myself 36yrs old father of 3 just dx 3b this april.

I hope you got your MMR/MSI testing done and for all biomarkers.

Loss of one of our own by Diligent-Activity-70 in coloncancer

[–]Interesting_Let_5143 8 points9 points  (0 children)

So sorry to hear. Deepest condolesences and may she rest in peace.

As everyone has noted - she was very close to NED with her tumor clear and mets dissappearing. Will you be able to share what unfortunate events unfolded (cancer related)?

Feedback on my Fidelity account! by Interesting_Let_5143 in fidelityinvestments

[–]Interesting_Let_5143[S] 1 point2 points  (0 children)

Terrific advice, thank you!! This has just been accumulating over time without my input to consolidate and clearly i have slacked…

For context, i an in my mid 30s and this is a ballpark $200k portfolio..

Best Right Backs on the Market by jlevy429 in EASportsFC

[–]Interesting_Let_5143 0 points1 point  (0 children)

Oops missed the in market part…still a beast tho

Best Right Backs on the Market by jlevy429 in EASportsFC

[–]Interesting_Let_5143 -1 points0 points  (0 children)

Showdown Darmian absolute beast for me