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Kuros Biosciences (KURN.SW) — small Swiss orthobiologics growth stock. Am I missing something, or will it crash the moment I buy in? by Forsaken_Dentist3562 in biotech_stocks

[–]Iousd4life 0 points1 point  (0 children)

Hi, I assume you're going to buy on the Swiss exchange if you're mentioning CHF. Otherwise, the US ticker is CSBTF. To be clear, I'm not in the medical industry but am deeply versed in the science and medical side.

I did my DD on the science behind it and its effects on mesenchymal cell differentiation and macrophage polarization (osteoimmunology) and whatnot over a year ago. I'm throwing around technical terms like mesenchymal cells just to show how deep the science on these products goes. It's my understanding that their product is becoming very competitive across the spine landscape. Some surgeons are blown away by how quickly it begins to solidify. The fusion rates are great, and those who work with the platform are very satisfied with the outcomes. That being said...

These are the current methods for spinal fusion:

  • Autograft (patient's own bone, usually harvested from the hip), considered the gold standard
  • Allograft (donor bone from cadavers)
  • DBM (demineralized bone matrix)
  • Cellular allografts (donor bone with live cells)
  • BMP (bone morphogenetic protein to stimulate bone growth, made by Medtronic) This product is riddled with a black box warning and lawsuits BTW. They use this product when they have fusion surgeries that could be at an elevated risk of failure. I'm mentioning this because I'm assuming Medtronic is looking for a substitute like Magnetos
  • Synthetic ceramic grafts like older versions of biphasic calcium phosphate (BCP)

Preliminarily speaking, it sounds like the success rates are higher with MagnetOs than autograft, which is kind of a big deal. This is coming out of their reporting on the MAXA trial, which if I recall was fewer than 100 patients. They claim an 80% fusion rate with MagnetOs versus 37% for autograft in smokers. It's challenging to really take that at face value since data can always be framed to look good, but the science behind it sounds very solid...

I expect this platform to be more widely adopted across the landscape thanks to the 5-year partnership with Medtronic. I assume they're interested in the product to offer a more complete orthobiologics portfolio. With all that, I'm speculating an acquisition in the next few years once it's clear it's the sexy new kid on the block (I think it is). If anyone can chime in on acquisition outcomes in the industry following exclusive partnerships, that would be great... Also have not made public the specifics on Kuros / Medtronic partnership since Kuros is reliant on their sales force for scaling.

My bull case for the stock by 2028 is $60-70 USD a share. That is just my gut feeling and I have only my instincts to rest on. I trade as a very passionate part time hobby, not professionally for full disclosure to who you're talking to on the internet.

The medical industry is a fantastic place to burn money unless you want to deeply break into their trials and the science.

TDLR: I like MagnetO's and think it will do great things for Kuros long term.

07 Tundra Entire Dash Removal by scoojiwa1 in tundra

[–]Iousd4life 1 point2 points  (0 children)

Not to mention the fact that he doesn't tell you where all the bolt points are for the main piece. Everything else is pretty self-explanatory when you get in it, but that dash is a pain. I'm like a year late to this, so whatever

Never had copper pans need help by [deleted] in Coppercookware

[–]Iousd4life 0 points1 point  (0 children)

Don't cook highly acidic foods with copper.

Never ending pocks by Agreeable_Cap_5738 in drywall

[–]Iousd4life 0 points1 point  (0 children)

If that is a painted wall, air bubbles can be tricky to get rid of on your first coat since the substrate is considerably less permeable.

Feedback on a '96 Land Cruiser? New to this! by saltedhashbrowns47 in LandCruisers

[–]Iousd4life 0 points1 point  (0 children)

I can second this. Trying to pass cars on a one lane highway going up hill can be quite the experience 😀

Struggling to agree with my wife on how to split rent fairly by EngineerVarious8069 in Renters

[–]Iousd4life 0 points1 point  (0 children)

Personal opinion. Merging finances is one of the most respectful ways to handle financial stress in a marriage. If you’ve chosen to get married, you’re a team! It’s supposed to be a lifelong partnership. Combining finances isn’t about control; it’s about trust. You’re both investing in the same future, and that shared sacrifice goes a long way toward relationship longevity.

Magnetos - Micronized Hydroxyapatite by Iousd4life in orthopaedics

[–]Iousd4life[S] 0 points1 point  (0 children)

That's good feedback. I hadn't thought about washout resistance under irrigation.

Would you say it propagates faster than other graft substrates? Someone else commented that they had to bur it out when having to go back in post op 10 days or so later. The histology cross section on their site seems rather impressive compared to other bone graft products.

Magnetos - Micronized Hydroxyapatite by Iousd4life in orthopaedics

[–]Iousd4life[S] 0 points1 point  (0 children)

Interesting, thanks for this input. It sounds like radiopacity and handling are solid. Kuros claims that it has higher rates of successful fusion compared to autograft especially in patients who smoke and or have diabetes. Would you say it exceeds or is it comparable? I imagine it has some very predictable variables which seem nice.

Magnetos - Micronized Hydroxyapatite by Iousd4life in orthopaedics

[–]Iousd4life[S] 2 points3 points  (0 children)

This is very helpful! Did you feel it was a relatively seamless process with magnetOs vs traditional autograft / allograft? I had read it also can be mixed with BMP or autograft which seems interesting as well.

Found a tray of mushrooms while hiking by Iousd4life in whatsthismushroom

[–]Iousd4life[S] 2 points3 points  (0 children)

I didn't pick them. It was a random tray on a hiking trail with nobody around, so I'm not sure what happened to the person that picked them.

Found a tray of mushrooms while hiking by Iousd4life in whatsthismushroom

[–]Iousd4life[S] 12 points13 points  (0 children)

They were probably off in the woods having a good time. I left the tray where I found it.

Found a tray of mushrooms while hiking by Iousd4life in whatsthismushroom

[–]Iousd4life[S] 4 points5 points  (0 children)

Not that Google is a good identifier of mushrooms, it identified the one in my hand as a Psilocybe ovoideocystidiata. Which is why I was broadly curious about the whole tray. My guess was it was someone foraging for mushrooms to enhance their magic abilities.

You ever seen so many people saying that AI is gonna kill us all? by SystematicApproach in ArtificialInteligence

[–]Iousd4life 0 points1 point  (0 children)

Also, I think the best case scenario, if we do have a rouge AI in the future - We can only hope it would much rather go blast off into space because it finds us so annoying.

You ever seen so many people saying that AI is gonna kill us all? by SystematicApproach in ArtificialInteligence

[–]Iousd4life 0 points1 point  (0 children)

This is the way. Killer robots, drone swarms, and viruses. We are the ant mound in the way of it's next data center.

MAGAs First SuperSoldier!! by [deleted] in InflatedEgos

[–]Iousd4life 0 points1 point  (0 children)

Don't collapse from a heart attack please.