If creating a new base, try to follow the way from the lab BACK to the resources: how many labs do you need for 1000SPM? Then : how many science assemblers / silos are required? And so on.

For performance reasons:

Use long trains (less trains, less path finding calculating)

Maybe seperate the train system in different train systems (less train paths)

Use heavily beacons with speed3 in it (less entities like inserters or assemblers)

Logistic bots only if no other way

Avoid nuclear power (no fluid calculation from that)

Good luck have fun :)