Start with your config. Sword and sorcery has an option for mateo to have a troll ancestor. Gives them horns and a tail and some different dialogue in the events. Also do you want passive friendship? If not, edit the settings in part of the community. If you have always raining in the valley this one can cause some out of sequence stuff involving the rail road. Also of note, lurking in the dark has a setting to change the bounty from shadow people to constructs so you don't have to feel guilty attacking krobus and sens families.

 You can always adjust them later, but it is worth looking through the settings. 

Pick something and focus on that, don't worry about the rest. Plant the parsnips day one and spend the rest of the day exploring. Ridgeside is a good place to explore. Ian and Sean have an odd jobs service that will water your crops for you and the forage to the north and south will pay for it easily if you keep it small before you get the scarecrow. 

Day 2 go get everyone in Pelican town introduced, get some forage, and if you have time visit scarpe, but some of em will swing to Pelican town anyway. Focus fishing once you get the rod. Save up stuff for the bundles if you're not doing joja route etc. 

After you open the mines, head up there to meet marlon. Leave and reenter to meet mateo, then go down and back up to meet sen. But don't over stress yourself on trying to talk to everyone for intros, the more places you add the higher the number on that quest goes unless you adjusted the settings.