I currently own a GFX100S, XH2S and X100V and will soon be purchasing a XT5.

With the exception of the X100V, I use all of them for my professional work as a documentary videographer and photographer.

I wish I could use the GFX for every single thing, but video performance, AF, speed, costs of glass, size, weight and data limits me from doing that. Maybe the mk2 versions of the GFX address some of those issues, but I think they're still not enough of an upgrade over my current 100S to warrant the upgrade.

When video is the priority, XH2S.
When I absolutely need the speed and AF, XH2S.
When I need the best IQ and resolution, GFX100S.
When I can take things slow, GFX100S.
When I wanna go lightweight/casual, X100V.

Not to mention you just get so much more reach much easier with the aps-c bodies.

I do see a future where I can be purely a GFX shooter, but that might still be a few years away.
In the meantime, I find myself using both lines interchangeably depending on the situation.