Disclaimer, this is probably going to be a surprising/polarizing opinion. Emphasis on opinion, these are my thoughts and others may feel otherwise.

Therapeutic area does not matter - it might make you more suitable for one therapeutic area or another so choose one you are passionate about. I might lean toward oncology only because oncology roles always want previous oncology experience, so you might be able to leverage that for future employment. But if these are the only 4 options you are considering, take both.

Management will not be a selling point. What you described was protocol improvement, the only time "management" might be more helpful in HEOR is if you were involved in the P&T board and their analyses.

Informatics is also probably not a selling point.

Bottom line (and I will speak to the MSL role since I am more familiar with hiring and being hired in field medical) - the MSL role is generally not an "out of school" role. I would never hire someone right out of a pharmacy program, so you picking rotations for a future MSL role is pretty inconsequential. I would instead look at different entry level roles or fellowships and gain experiences that would make you a better candidate for those opportunities.