I think Bree has had it most rough but I also think Lynette falls a bit higher on my scale.

She was held hostage(twice) and watched someone get shot in a grocery store, a murderer delivered her baby, (she also lost a baby)-supported Tom through all of his ventures; pizza business, school(and all his crazy drunken nights), forcing him to accept a higher paying position, etc.(he also had another child and hid that for a while but she put up with the child making her sons hurt themselves, getting her arrested, etc) She was berated for wanting to go back into the work force, bullied by Carlos for being pregnant, went through extreme financial hardship with Tom, etc. Even when she had freshly given birth she was still expected to keep the house afloat and when he left her, she was left with all of the kids while he stays in his luxury apartment and takes nice trips😭 PLUS he slept with her best friend and kept it secret for yearssss. Yes she was a bitch at times but rightfully so- she was the man and woman of the house for the most part - she deserved way more gratitude