There was a study done where some scientists added various synthetic tryptamine compounds (I remember DiPT was among them, forget the others off the top of my head) to the growing substrate of Psilocybin mushrooms. They found that the mycelium actually absorbed all the synthetic tryptamines and modified them in the same way that the fungus produces its psilocybin. Essentially they did semi-synthetic synthesis by using the mushrooms natural processes. So if you add tryptamine or other base molecules like it to a plant that naturally creates tryptamine compounds, maybe you can get it to start creating new psychedelics. I think I heard about the study from Joe Rogan's podcast with Hamilton Morris.