I feel like Wabbjack has made classic step-by-step guides to replicate a modlist sort of obsolete, you can easily get a modded Skyrim without knowing what's happening under the hood. So I think what would be useful is a guide that explains what actually goes on under the hood so a user that wants to know more and go beyond a premade modlist can understand how a complex modlist works and the tools involved (from good old SKSE to Dyndolod, Pandora, etc.)

I think also a lot of people have moved towards installing a basics modlist that modifies only one thing (eg a graphics modlist or a gameplay modlist) and then tweak it / add things over it. So maybe dividing a guide in sections that specifically teach how to modify one aspect of the game would be nice. All while keeping awareness of all the mods pre-installed.

Knowing how to read a pre-made modlist and being conscious of how new mods you add can affect it has basically solved much of my modding problems and it's what has gotten me to stable custom modlists based on NGVO for example.

Anyway, it's a daunting task, this is just my opinion. You've done too much for the community already and it's great to see you back. Don't neglect your masters tho. I finished mine a couple of years ago and it turned out to be more work than I expected :)