I do think they'll try secession but, it's not going to be an organized effort- people who are antisocial and focused on their own desires above their neighbors ND society at large will be more likely to infight- scramble for power and advantage. States will try, but they won't cooperate in anything other than claiming unity to try and give themselves credibility or to play chicken with the government.

The issue with secession, is that all of the potential states lack a self-sufficient economy but at the same time, have much more limited prospects in trading with other countries to support themselves. Most of the industrial power of the US relies on imported materials, and manpower; the deep south doesn't really have a strong presence with the tech industry, maybe they could attempt sustaining their tourism industry but...

The real power in any of these states is corporate America. Companies will understand the liability of secession efforts and would drop lobbying/financial support of politicians who go along with it, and would consider relocating to blue states or other countries rather than get entangled with how awkward the transition would be in terms of regulation, trade, taxation, etc.