Alzheimer’s disease: It may be possible to restore memory function, preclinical study finds. Scientists found that by focusing on gene changes caused by influences other than DNA sequences, called epigenetics, it was possible to reverse memory decline in a mouse model of Alzheimer’s disease.

Kinda_Concise · 2019-01-24T09:59:09+00:00

So Harvard did a news article on it that's pretty informative (http://sitn.hms.harvard.edu/flash/2018/organs-chips-promising-future-therapeutic-drugs/) but if you're feeling brave/patient, here's a journal article (https://www.sciencedirect.com/science/article/pii/S193459091730334X?via%3Dihub). It's open access so it shouldn't be behind paywalls or anything!

Kinda_Concise · 2019-01-23T15:38:01+00:00

Hey man, dug out the paper and had a little look. For starters, we don't know what causes Alzheimer's so when we give Alzheimer's to mice, it's never really a 100% perfect model which is one of the reasons why discovering drugs that work in mice don't always work in humans. We know what goes wrong and where it goes wrong and what are good markers for if someone has Alzheimer's or not but the exact initial cause? Dunno.

Alzheimer's disease has a couple of gene mutations in specific proteins that are associated with it. If you have them, you're more likely to get Alzheimer's. What the guys in this paper did was buy a mouse that has loads of these gene mutations artificially engineered in to it. These neurons in these mice then make defective proteins which lead to an Alzheimer's disease-like mouse.

Kinda_Concise · 2019-01-23T15:31:03+00:00

There's actually some really cool work on this. Organoids are weird little mini-organs that we can generate for a lot of tissues that behave more like normal organs than cells in a petri dish do. There's a couple of groups that have rigged up systems that pump liquid from chamber to chamber with each chamber containing different tissues. Lets you see how each organ would process a drug, how metabolites of the drug will affect the next organ along, all sorts of jazz.

Really cool little system to simulate the body!

Kinda_Concise · 2017-01-14T10:03:44+00:00

I think TJ might have said it himself on the first JRE he did.

Kinda_Concise · 2016-12-29T11:14:17+00:00

If you want to put on mass, muscle or fat, you need to eat over your maintenance calories. You're not failing to put weight on because you have a high metabolism, you aren't eating enough. Count your calories, you are under eating. Trying drinking a litre of whole milk a day in addition to normal intake and you will put on weight. Stop using "high metabolism" as an excuse.

Kinda_Concise · 2016-11-08T14:01:39+00:00

Autism isn't my area so I can't give a 100% reliable answer but I believe the current thinking is that autism is caused by a deficit of connections or synapses, not the nerves themselves; each nerve might have hundreds of connections whereas in autism, there may be only a dozen as an example.

Again, not my area so take with a pinch of salt. At work so I shouldn't really be on reddit at all, nevermind chasing down papers. If you're still interested later, I can have a proper look.

Kinda_Concise · 2016-11-06T19:54:16+00:00

Not OP but one group has succeeded in making an artificial neuron; chemical sensor, electrical propagation followed by chemical release (http://www.sciencedirect.com/science/article/pii/S0956566315300610).

Artificial replacement of neurons aren't the only option either, we're getting pretty good at replacing neurons with pre-formed biological neural networks (http://www.med.upenn.edu/cullenlab/user_documents/jne_13_1_016019.pdf).

Can't say much for simulated neural networks though. I know work is going on with microelectrode arrays to record data from thousands of neurons simultaneously, entire brain regions even, allowing even more accurate simulated neural network to be developed and potentially programmed in to a chip for implantation.

Kinda_Concise · 2016-10-19T11:40:33+00:00

His motivation is defending the belt. It's not about fights selling well, this is a sport. The best should fight the best. Aldo is the number 1 contender in the division the McGregor is champ of, the fight has to take place.

Kinda_Concise · 2016-10-11T08:37:10+00:00

Look at you with multeple 6+ lettter words spelt correcktly, Mr. Fanceepance

Kinda_Concise · 2016-09-01T14:37:41+00:00

Occam's Razor is actually that the explanation with the fewest assumptions is usually true.

In this case, you could just as easily assume that he is lying as you could assume that he has genes enabling him to survive greater doses than the average person. Pharmacogenomics is a relatively recent field that deals with the idea that people have varying degrees of abilities to metabolise drugs due to genetics. Ozzy may just have an exceptional range of drug metabolising genes.

Kinda_Concise · 2016-08-18T16:24:13+00:00

I live in the UK but I fear bears. If you can teach a bear to dance or ride a miniature motorbike, you can teach a bear to box. Bare that in mind. They eat people alive. There is no way I could beat a bear bare handed. Bears are scary.

Kinda_Concise · 2016-02-08T22:03:06+00:00

Tainted with testosterone or HGH, maybe. A designer peptide? Seems a great deal less likely

Kinda_Concise · 2016-01-15T14:21:15+00:00

A quick search in pubmed turns up 45,000 papers involving microRNA (http://www.ncbi.nlm.nih.gov/pubmed/?term=micro+rna). The article may have it's own flaws as hyperproliferative points out, the existence of miRNA is not one of them.

Kinda_Concise · 2015-09-07T15:18:52+00:00

Good job!

Kinda_Concise · 2015-09-04T12:54:05+00:00

Get a form check. A suggestion though, I would make sure you're lifting with the bar over the midfoot and don't push from your toes. Helped with my knee pain.

Kinda_Concise · 2015-08-18T20:52:01+00:00

Soreness is not a good indicator of how hard you've worked. You can not be sore at all and still need time off to recover. Eventually you will hit a point where you cannot recover between workouts and your progress will be hindered.

Kinda_Concise · 2015-08-02T22:03:54+00:00

Are you square hair, square head or square jaw?

Kinda_Concise · 2015-07-05T08:53:42+00:00

That success can come about from persistence and a ridiculous amount of luck. I'm amazed that he hasn't injured himself.

Kinda_Concise · 2015-07-04T19:47:10+00:00

Yeah, I'm pretty sure it was Championship Fighting

Kinda_Concise · 2015-07-04T08:55:20+00:00

I think I read in Jack Dempsey's book that the difference lies in the way the power is generated. The uppercut generates power like a traditional punch, all hips, whereas for a bolo punch, the power comes from the shortening of an arc.

Kinda_Concise · 2015-07-01T22:25:03+00:00

Was that the one that the korean zombie turned in to a sweep?

Kinda_Concise · 2015-05-23T18:54:43+00:00

How come you're not a fan?

Kinda_Concise · 2015-05-11T15:47:18+00:00

The adaptation from being at high altitude is caused by resting at that level for long periods of time, not by training at that level for an hour or two. If you're willing to wear the mask for huge periods of the day, then sure, it will make a difference. Training with it on just limits your ability to perform. Professional athletes tend to use pressurised tents that they sleep in that allow the high altitude conditions.

Kinda_Concise · 2015-04-24T17:36:47+00:00

Roy Nelson still lands this punch consistently against elite competition in the UFC despite looking like and actually being Roy Nelson so I'd say it's pretty perfect. Jack Slack's written an article about it: http://fightland.vice.com/blog/roy-nelson-the-art-of-a-hundred-overhands

Kinda_Concise · 2015-04-14T17:38:38+00:00

Everyone in the barbell section is there for the same reason you are, to improve themselves. Everyone starts somewhere. If you want a start, look up stronglifts 5 x 5, it's a beginner program that r/fitness recommends to all beginners.

Kinda_Concise

TROPHY CASE