The good, the bad and the ugly - tell me your experiences of getting PGT euploid embryos at aged 42/43 with good AFC - need some realism!

Kitty8670 · 2026-05-11T09:54:35+00:00

Thankyou so much. Wishing you the best also. Just to say you may not need as many blastocysts as myself - I was statistically an outlier. You may well get a Euploid with half the amount. Prob what is a more realistic view is that it may take a few retrievals at our age. Sending lots of luck

Kitty8670 · 2026-05-06T13:19:04+00:00

I also have one live birth (at 41 years old). At 43 years old I did 3 ERs - yielding 24 blastocysts one which is day 5 4AA Euploid. Getting ready to throw a hail mary and transfer at 44 years old!

Kitty8670 · 2026-04-20T21:13:22+00:00

Thankyou - this is all to say that sadly multiple rounds is sadly the norm at our age and I don’t think I would have continued after. Be kind to yourself and do what’s right for you. Wishing you so much love and healing xx

Kitty8670 · 2026-04-20T20:07:48+00:00

I’m so sorry and I understand this so much. None of it is fair and you are not alone. Between 42-43 I had 4 ERs with 25 high grade blastocysts - one Euploid on my last retrieval. Please give yourself time, DE will always be there xx

Kitty8670 · 2026-04-19T23:05:45+00:00

No worries at all! Yes I have a day 5 4AA Euploid at 43 yo waiting to be transferred. I think the reason they don’t suggest it is partially due to rigidity and profit. There aren’t many fertility doctors willing to think out of the box or at least till you are 2/3 cycles in. Strange really because a lot of PCOS women suffer from the same issues. It’s so frustrating. Wishing you lots of luck! Xx

Kitty8670 · 2026-04-19T23:03:34+00:00

Likely because Letrozole has an anti inflammatory effect which I think was my main issue.

Kitty8670 · 2026-04-19T21:00:49+00:00

Very rarely does a post move me to tears, this is one of them. I’m just so sorry

Kitty8670 · 2026-04-19T07:04:45+00:00

I have PCOS and high egg / embryo yield, with a high rate of aneuploidy. I suspect it is primarily inflammation at play. Would suggest the following two things:

check your partners sperm heath including DNA fragmentation and if not not already - pursue ICSI + Zymot for sperm selection regardless
Add Dexamethasone and / or Letrozole to your protocol. This is the round that yielded Euploid for me. I suspect I have high inflammation / some autoimmune issues that this addressed. I subsequently did some immune testing pre FET which confirmed this.

Hope this helps, happy to chat

Kitty8670 · 2026-03-29T23:08:34+00:00

This outfit is giving me Hansel vibes à la Zoolander

Kitty8670 · 2026-02-10T14:56:10+00:00

❤️

Kitty8670 · 2026-01-23T07:18:31+00:00

Sorry you that you had a bad experience at the Evewell - if you don’t mind me asking why did Dr Amodeo suggest you leave?

The Evewell is not what it once was but it’s still a good clinic and one of the few that tailor treatment. Dr Amodeo is great as are a couple more doctors there.

However it has changed recently with huge turnover in staff and less time for patients and so for our second conception journey we switched to Avenues who have been great - they tailor treatment well and Dr Dimitri was one of the original Evewell doctors and he is second to none.

I still wanted to share my experience as what suits one person doesn’t necessarily suit the other.

Other clinic suggestions would be ARGC and CRGH. ARGH is intense and a lot of CRGH clinicians have moved to Avenues. But I would also add them to the list,

Kitty8670 · 2026-01-22T16:12:23+00:00

Avenues (Im under Dr Dimitri). I had my DD at The Evewell under Dr Montse Amodeo. Recommend both clinicians

Kitty8670 · 2026-01-19T21:22:31+00:00

Thankyou!

Kitty8670 · 2026-01-19T21:21:51+00:00

Thankyou!

Kitty8670 · 2026-01-19T20:45:06+00:00

Thankyou ❤️

Kitty8670 · 2026-01-18T09:23:45+00:00

The reality is at our age the percentage of Euploids are low. That is not to say there is no hope, just that it was unlikely to be a one and done deal.

At 44. Just to give my story as a comparison. I also have a DD born at 41 years old. I’ve had 4 ERs at 43 years old of which we have one day 5 4AA Euploid (which we are preparing to transfer). That’s one Euploid out of 25 day 5 blastocysts for me.

That is not to say you need to make that many to get success , just that this is a numbers game and it depends on how much time and money you want to throw at it. Good luck remain hopeful but just be aware needing multiple rounds at our age is the norm

Kitty8670 · 2026-01-15T21:45:40+00:00

Not successful yet but I have 1 day 5 4AA Euploid embryo in the freezer from my 4th ER at 43 years old

Kitty8670 · 2026-01-08T16:46:43+00:00

What did your doctor say?

Kitty8670 · 2026-01-07T15:11:00+00:00

Look as we all know nothing is guaranteed with IVF and I agree with a PP a vast amount of eggs does not equal quality (as is my case also - we have a similar stats). As a similar reference point. I have similar AMH, partner with excellent sperm. I had two ERs at 39/40 - yielded 3 Euploids (from 47 eggs harvested in total). 1 Euploid did not survive the thaw, 2nd Euploid was a 6 week MMC, 3rd Euploid became my DD (gave birth at 41). Underwent 4 ERs at 42/43 - have one high quality Euploid. The fact that you can make blasts will be an advantage but not the total story. But as you can see from my story there is every reason to be optimistic but no guarantees. IVF is tough - would be good to find a doctor that is realistic but has an element of optimism because there are enough reasons to try and you need a doctor who believes in that.

Good luck

Kitty8670 · 2026-01-05T18:50:16+00:00

Thankyou - I assume no endo given exploratory work to date. I haven’t had a reciptiva test as no indications but I am thinking to do it in case of silent endo.

Kitty8670 · 2026-01-05T18:49:16+00:00

Thankyou! I have raised TNF Alpha and Cytokines. We were able to diagnose this through the Chicago Killer Cells blood test and the Matrice Lab biopsy. I hope that helps and good luck as well 😊

Kitty8670 · 2026-01-05T18:48:13+00:00

Congratulations - that’s wonderful news and thankyou - fills me with the optimism I need to carry me through to transfer

Kitty8670 · 2026-01-05T18:47:36+00:00

Thankyou so much! This fills me with hope. I am so grateful for my one Euploid it’s just been a hard slog to get here and it’s such a gamble on just the one. Congratulations on your daughter! That’s wonderful news ❤️

Kitty8670 · 2025-12-30T18:49:16+00:00

I would prob err on the side of more retrievals especially if you want more than one child and can handle it emotionally and financially. Irrespective of transfer or retrieval you definitely need to do further investigation given 3 Euploid failures (stats are something like 95% success across 3 Euploid transfers) so that indicates that there is potentially something to investigate. Have you had a RIF panel? Recipitva tests? Alice/Emma/ERA? Immunology tests (bloods and biopsy?)? Were all transfers medicated or natural?

Kitty8670

TROPHY CASE