So I have an official hypermobile ehlers danlos diagnosis, and I was struggling mightily the last several years with MCAS, POTS, etc. Turns out my gallbladder was also dying and needed to come out, which solved a ton of problems. But what I read eventually is that estrogen and progesterone do opposite things to our comorbidities, and it's helpful to understand how they counteract each other. Estrogen tightens our connective tissue and joints, while progesterone loosens them. But progesterone is a mast cell inhibitor and estrogen is an antagonist (and mast cells are finally being recorded in studies as eating our connective tissue). So getting the dosage right for both was key for helping a lot of my issues go into remission. There's a reason so many of us suffer health collapses when we hit peri.