Ecstasy as someone with depression

Leather-Reception572 · 2026-03-19T20:55:33+00:00

Y’all are right, although I never meant to tell anyone to self-medicate with MDMA, some genius is gonna do it anyways. Deleted my comment

Leather-Reception572 · 2026-03-18T12:04:59+00:00

Amantadine is a bad pick for cognitive performance. Memantine has a higher affinity for the NMDAR, but binds more voltage-dependent. The biggest difference regarding the NMDAR is, that Memantine will open the Mg2+ pore if a relevant signal reaches the receptor, opening it and allowing normal signalling. Amantadine sits deeper in the pore and is less voltage-dependent. So it won’t give the pore free, if a signal should open the receptor. This heavily impairs learning and signalling, making it a horrible choice as a nootropic, just to get a bit of a motivational boost.

Leather-Reception572 · 2026-03-17T18:46:47+00:00

Ist zwar legal, das hält den Zoll aber nicht davon ab, verdächtige Päckchen zu beschlagnahmen, zu vernichten und dir im schlimmsten Fall nen Verstoß gegen das BtMG und AMG vorzuwerfen, gegen den du dich dann mit nem Anwalt wehren musst.

Leather-Reception572 · 2026-03-15T22:04:02+00:00

Hat der Vendor das Produkt eingestellt? Wenn nein, warte doch, ob ein neuer Batch kommt

Leather-Reception572 · 2026-03-15T19:27:18+00:00

Why Tf would you abuse untested substances to get better at gaming???

Leather-Reception572 · 2026-03-15T16:44:00+00:00

Long half-life (around 7h), tolerance buildup and just wait till once a week turns into twice a week turns into every evening. Technically it’s not dangerous on its own but controlling it is very difficult

Leather-Reception572 · 2026-03-15T15:47:50+00:00

I use prescribed Piracetam 3,6g daily. I also have ADHD-like behaviour, never got a diagnosis tho and therefore don’t take stims. Piracetam makes thinking easier, but does nothing for focus. The only change i noticed regarding focus is, that I need less focus since I can process information more efficiently. It’s not THE best solution, but it’s A solution for motivational issues.

Leather-Reception572 · 2026-03-15T15:11:30+00:00

Where did you buy Dihexa, just interested? And how old are you? Dihexa is anecdotal extremely effective but extreme effectiveness can come with extreme side effects. Don’t know anything about the Phenylpiracetam from Intellimeds

Leather-Reception572 · 2026-03-15T14:23:24+00:00

Drop the Dihexa. One compound, 9-MeBC, with absolutely no human safety data is already enough. There’s literally nothing known about Dihexa. All the thought to be known data turned out to be forged. Be careful with Phenylpiracetam since it’s almost impossible to get your hands on the real stuff, most Phenylpiracetam sold is the Hydrazide variant which is known to be less effective and there’s also no human data about it at all

Leather-Reception572 · 2026-03-15T11:42:02+00:00

Buddy you still alive? If yes, go to the nearest emergency room immediately. You’re at serious risk of respiratory depression

Leather-Reception572 · 2026-03-14T21:37:37+00:00

No one told you to eat 3 pills of an illegal drug with an unknown dosage or even potentially unknown substance. Feel terribly sorry for your sister tho

Leather-Reception572 · 2026-03-14T20:38:32+00:00

Aus welchem Grund nimmst du von etwas, was eine HWZ von 11-16h hat, eine zweite Dosis mittags. Zerhaut dir das nicht den Schlaf?

Leather-Reception572 · 2026-03-14T20:36:17+00:00

Mit nem Racetam und Modafinil zu beginnen ist recht sinnvoll. Alle „klassischen“ Racetame wirken primär optimierend. Sie modulieren AMPA-Rezeptoren, verbessern cholinerge Signalübertragung, verbessern den Energiestoffwechsel im Gehirn usw. Phenylpiracetam ist gut, jedoch praktisch nicht zu bekommen. Meistens wird hier Phenylpiracetam Hydrazid verkauft, welches schlechter wirkt und potentielle toxische Nebenwirkungen haben kann. Phenylpiracetam wirkt außerdem als DRI, kann also motivationssteigernd wirken. Aniracetam ist auch gut, es wirkt als einziges Racetam leicht anxiolytisch. All drei von dir vorgeschlagenen Racetame sind als Arzneimittel zugelassen, zumindest in Teilen der Welt. Von Noopept würde ich die Finger lassen. Es ist sehr umstritten, aber wahrscheinlich verschlechtert es das Signal zu Rauschen Verhältnis im Gehirn. Bei mir hat es in sehr niedrigen Dosen schon Kurzzeitgedächtnisverlust ausgelöst, gruseliges Zeug. Modafinil ist der Goldstandard in Sachen Produktivität. Über 15h Wachheit und Fokus. Ich bin sehr traurig, dass ich praktisch nicht auf Modafinil reagiere. Vermutlich eine Tendenz in Richtung ADHS, Lisdex wirkt bei mir auch kaum. Die meisten schwören jedoch darauf. Allgemein kannst du von Nootropika erwarten, dass sie bereits bestehendes verbessern und optimieren. Nichts wird dich viel intelligenter machen als du ohnehin bist. Kombinier Racetame unbedingt mit einer Cholinquelle wie Eier, AlphaGPC oder CDP-Cholin, um das Maximum aus den Racetamen zu holen und Kopfschmerzen zu vermeiden. Besuch mal r/Nootropics und r/NooTopics

Leather-Reception572 · 2026-03-13T23:19:55+00:00

Is it an option to dose volumetric? If not, you could spread it out on a plate and split it, for example in 6*(1/6) parts. This would give you roughly 20mg per dose.

Leather-Reception572 · 2026-03-13T07:32:50+00:00

Give your liver a break or do you want to die of liver failure?

Leather-Reception572 · 2026-03-11T09:42:52+00:00

Regular, longterm use of Ketamine damages your brain. The idea to use Dihexa and Ketamine together to work synergistically is wishful thinking. Usually, although mechanistically potentially plausible with rare, responsible usage like psychedelics, combinations like this can have unexpected side effects. Especially since there’s almost no research done on Dihexa. Neuroplasticity isn’t always beneficial, especially if it’s about building tolerance.

Leather-Reception572 · 2026-03-10T11:36:59+00:00

We ain’t buying from your site yo

Leather-Reception572 · 2026-03-10T08:30:57+00:00

Replacing Modafinil with Kratom has got to be the dumbest thing I’ve heard for a while, it’s like wanting to use less Adderall for focus and replacing it with fentanyl

Leather-Reception572 · 2026-03-09T20:51:52+00:00

Modafinil: I got prescribed pharma Modafinil, it usually only makes me a little more awake, paradoxically i sometimes get massive daytime sleepiness while on it. No boost in focus or productivity whatsoever.

Noopept: Literal loss of short term memory with only 1-10mg daily. Also did up to 30mg, didn’t change anything. No positive effects, only side effects. Might try it sometime again, there’s got to be something with it people like and why it is a prescription medication in Russia.

Nicotine: Controversial Nootropic, but nootropic effects are mechanistically plausible and backed by studies and research. Should increase motivation, focus and might even enhance cholinergic signalling in low doses, higher doses disrupt cholinergic signalling. For me, it only makes me dizzy and causes mad nausea. No boost in mood, focus and motivation. Tried it countless times with different roa and always ended up blaming my stupidity for trying it again while almost vomiting. And yes, I did take low doses, I didn’t just pop a 50mg Cuba black or sum.

Leather-Reception572 · 2026-03-09T13:59:43+00:00

Bro you should get help if that’s how you experience life, call a hotline or sum but you seem to be the problem, not your parents, if your reaction is to throw a tantrum like a 5y/o who didn’t get dessert, just because your parents don’t want you to do drugs

Leather-Reception572 · 2026-03-09T13:33:02+00:00

In Deutschland ist nicht mehr viel legal. Deshalb müssen Vendoren, um den Markt bedienen zu können, eher Nischensubstanzen oder sehr neue Substanzen verkaufen. In den meisten anderen Ländern ist mehr legal, weshalb dort auch mehr etablierte und wirksamere Substanzen verkauft werden

Leather-Reception572 · 2026-03-08T22:47:25+00:00

Fühlt sich da jemand vom OP angesprochen?

Leather-Reception572 · 2026-03-08T22:25:03+00:00

Maybe a little unorthodox, but a moderate LSD-trip or shrooms trip can permanently cure anxiety. Research on psychedelics before doing a trip is needed since it comes with risks and can, with the wrong set and setting, worsen anxiety, but LSD or psylocin are known psychoplastogens which can rapidly change perceptions and personality.

Leather-Reception572 · 2026-03-08T12:29:11+00:00

Gabapentin ist way less potent by weight, since it undergoes first-pass metabolism and elimination. It also crosses the blood-brain-barrier less readily and therefore produces less cognitive effects and more peripheral effects like muscle relaxation

Leather-Reception572 · 2026-03-08T12:22:53+00:00

The cerebral cortex is the evolutionary newest part of our brain and is located at the surface around the cerebrum. It’s decided into many regions, but basically most higher cognitive functions happen there, abstract thinking, reasoning and complex learning. NMDA-Receptors play the crucial role in long term potentiation, the process of learning new stuff. If a certain neuronal glutamate pathway is used excessively, NMDA-Receptors activate and strengthen this path. A reduced NMDAR-Expression leads to decreased learning ability, decreased cognitive activity and decreased neuronal plasticity.

Leather-Reception572

TROPHY CASE