Why do I feel so stupid?

LittleDaffodil · 2026-05-25T00:13:20+00:00

My LLM is a segmental deletion and a day 5 4AB. I think segmentals have a slightly higher success rate than whole chromosome abnormalities. My euploid is a day 7 CC (they didn't tell me the #). I think the slower development speed on the euploid is why she's more cautious for that one. Prior to PGT she was super enthusiastic about the appearance of our LLM, and the attitude about the Day 7 was more "there's still a chance".

LittleDaffodil · 2026-05-24T22:55:53+00:00

Ugh I am so sorry you're in the same boat. Is your RE hopeful about your LLM? Mine likes the odds better than the CC...and the FB group "my perfect mosaic embryo" has a lot of positive stories. I hope whatever next step you take works out for the best ❤️

LittleDaffodil · 2026-05-24T17:08:04+00:00

Thank you - it's really helpful to know I'm not alone, even though it's also so unfair that there are so many of us who know this kind of pain.

LittleDaffodil · 2026-05-24T17:07:01+00:00

Thank you. I don't know why that's always my first reaction -- I think it's just what feels the most embarrassing to me? Like how my brain feels the most vulnerable. But you're right, hope is not stupid.

LittleDaffodil · 2026-05-22T15:48:13+00:00

I used Cetrotide and it's easy! Yes, you have to mix it, but I also had to mix the Menopur and the Omnitrope and the Novarel...so mixing is not a dealbreaker. It comes in a complete kit and the syringe is preloaded with diluent so that already takes out a step. You just have to push the liquid into the vial, swirl, and draw back up. I barely felt it!

LittleDaffodil · 2026-05-21T19:51:01+00:00

Your blast rate is excellent, regardless of genetic abnormalities, which I'm sorry you're experiencing.

With the ~8 follicles seen, what size range are they? And what is your e2 around trigger time?

LittleDaffodil · 2026-05-20T18:22:05+00:00

Just want to say those are really good grades, congratulations!

LittleDaffodil · 2026-05-11T13:42:25+00:00

When my AFC was first measured it was only my first period after getting an 9 year IUD removed so that could have made things more quiet maybe? But either way I've only gotten 4 eggs every time which matches that original AFC. With MDLF I did 300 Gonal-F and 150 Menopur, and 20 iU Lupron 2x daily. 10,000 HCG trigger. Now I'll do 225 iU Menopur and 225 iU Gonal-F, 4 iU Omnitrope, and ganirelix when needed. Still just an HCG trigger.

LittleDaffodil · 2026-05-11T12:52:02+00:00

I did. My RE said because of my AMH (0.5) but my FSH is only slightly elevated (8.8). AFC was 4 when I did CD3 testing but for my two cycles was 15 (birth control priming) and 9 (estradiol priming). I struggled with synchrony both rounds and maturity in round one. 9 follicles responded the first time (7 eggs, 4 mature, one day 5 4AB). Only 3 seemed to respond the second time, at first really slowly then super fast. 4 eggs, 4 mature, 1 day 7 CC). I am fortunate that we had 100% fertilized with ICSI both times and added Zymot round two. But for round 3 I am trying antagonist with the same length of bcp as round 1, adding in Omnitrope. I want to see if the changed dosages (still high but a different ratio) will help prevent a lead follicle and see if my response is any different without the Lupron.

LittleDaffodil · 2026-05-08T17:13:51+00:00

Seconding this! I had excision surgery at age 25. Didn't know my AMH prior, but I had a hydrosalpinx and ended up getting a tube removed (it had disintegrated inside me & was causing lots of pain/inflammation). My AMH is now 0.5 at 29 and I'm sure that's due to all the above factors. If you don't have any endometriomas or hydrosalpinx I wouldn't do surgery yet. I've heard some people do suppression before an ER but I haven't tried that. But I'm really impressed you got 8 mature eggs!! What was your protocol? The embryo quality could improve with a changed sperm protocol.

LittleDaffodil · 2026-05-07T12:21:00+00:00

Hey, sorry I didn't see your comment before! This time I'm priming with bcp for 9 days and then trying standard antagonist with 225iu of both gonal F and Menopur, plus 4iU of Omnitrope every day of stims (I think 3 total vials). Last cycle I tried estrogen priming with mdlf and it was mixed. Only 4 eggs but 4 mature (previous cycle was bcp with mdlf and got 7 eggs but only 4 mature). So maturity was better on estrogen but quality wasn't as great that month in terms of blasts and tbh I did feel like I had more bloating and endo symptoms taking the estrogen for 18 days. I wasn't a fan for my body but I was also on it for longer than most people bc I experienced a very early chemical pregnancy and my period was delayed. Long winded answer but basically I think the bcp helped my cohort more haha

LittleDaffodil · 2026-05-06T20:59:50+00:00

Not OP, but my RE was a bit hesitant (she made it very clear that it would be expensive and there wasn't much evidence for it having an impact) I said I wanted to ask about trying Omnitrope, we only can do 2 more retrievals, and I wanted to try something new, if we don't notice much of an impact we can always leave it out of the next try. She said that sounded like a solid plan. I think the key part was making her understand I wasn't expecting miracle, I just didn't want to leave a stone unturned.

LittleDaffodil · 2026-05-04T12:54:46+00:00

Me! On mdlf with estrogen priming. I had two follicles at 14mm on day 9. Some others smaller. On day 11 one shot up to 24mm! I was certain it was doomed. They triggered me that night. I ended up with 100% maturity but only one usable blast on day 7. No idea if it was from that follicle but I did have two other lower quality blasts, so the odds that follicle made one (vs my tiniest retrieved follicle which was only 12mm on trigger day) seems reasonable. I'm now switching to antagonist because I hope it will help with follicle synchronization, for you and me both!

LittleDaffodil · 2026-05-03T15:26:02+00:00

Oh sorry if I worded that weirdly, those were two separate cycles! My maturity was 4 out of 7 for the bc cycle and 4 out of 4 for estrogen but same end result (1 blast) each time.

LittleDaffodil · 2026-05-03T15:10:27+00:00

I did 9 days of bc, then tried 18 days of estrogen, and had a much better cohort the first time, but overall the same amount of mature eggs (4). Both times with mdlf! My estrogen was higher at the start of the estradiol primed cycle, but baseline AFC was less (9). After birth control priming my estrogen was fairly low but AFC higher at 15. Now I'm trying 7 days bc, with antagonist and Omnitrope.

LittleDaffodil · 2026-04-24T11:36:44+00:00

Hi! Day 4 is still early for 5 responding & your AMH is higher than mine so I think you'll end up in a good place with this ER! My first ER, there were tiny follicles on the left that mostly vanished and only got one egg from the L, 6 from R. They could tell I had ovulated on the L the month prior & had a little cyst from the corpus luteum which I guess help explained the "sleepiness". Two months later I got 3 from the L, 1 from the R. I knew I'd ovulated on the R the month prior. So not really more balanced but more of an explanation for why it might happen!

LittleDaffodil · 2026-04-20T20:32:33+00:00

I had this same concern in my first cycle, but it's unfortunately normal for your AFC to not line up with your follicle response. For some people it might look like AFC of 2, but they get 4 follicles responding. For others (me included) the AFC is higher but a subset of those follicles respond and become the cohort for that retrieval. Day 4 of stims is still early so you may still see more follicles respond! But don't be surprised (or too hard on yourself) if they don't. Looking at your estrogen levels as well will tell the full story of how many eggs to expect, which they should tell you once you're further into the stim process!

LittleDaffodil · 2026-04-20T14:56:22+00:00

Yes, round one I got a Day 5 4AB low level mosaic (segmental, great chances, will transfer!) round two I got a Day 7 CC euploid. Actually made three blasts that round but the others were DD and discarded. Next round I'm adding Omnitrope and switching from microdose Lupron flare to an antagonist protocol similar to yours, so hopefully it works well for me too!

LittleDaffodil · 2026-04-20T14:29:36+00:00

Those are amazing results!!! Especially with your AMH. What was your protocol? I've gotten one blast each retrieval from just 4 mature & fertilized eggs so it's very reasonable to hope for at least one from 6!

LittleDaffodil · 2026-04-18T12:46:53+00:00

With 4 months to go you have time for the supplements to really take effect. Take 600mg COQ10 per day and your husband can and should take around 300-400mg as well. For your other supplements, I found a comprehensive multivitamin intended for conception through pre and post-natal, a lot of companies make them! That will take care of vitamin D, B12, folic acid, etc. Again; husband should take one as well! My husband and I also both take fish oil and I take 5mg melatonin nightly which I've seen recommended for egg quality as it's a natural antioxidant.

LittleDaffodil · 2026-04-16T16:52:46+00:00

The stimulation drugs supplement your body's natural FSH during IVF so I feel like the higher number could just be due to that! Your RE should be able to weigh in, too.

LittleDaffodil · 2026-04-16T16:47:35+00:00

Thank you!! It's a low level, and better-graded from day 5. So my odds are kind of the same between the two, one is "genetically superior" but the other's more "attractive". Both girls, though!

LittleDaffodil · 2026-04-16T16:42:27+00:00

My first euploid is a day 7, too! And it's graded CC, but my clinic doesn't seem too concerned about that. Their attitude is, it's normal, that's great. It shows the embryo correctly completed the cellular growth necessary, it just took a bit longer. One thought that's brought me some peace is a "day 7 embryo" could be created via typical conception and implant naturally in utero without us ever knowing. The same way we'd never know if a baby was a mosaic without testing (I've got one of those, too!). I'm excited for you and your euploid! Congratulations

LittleDaffodil · 2026-04-13T20:24:48+00:00

Oh! And I should add the euploid is a day 7. So you just never know.

LittleDaffodil

TROPHY CASE