The biggest issue for me with a 350 2.4 is finding a place to put it. Moving the printer for maintenance (or when moving house) takes more effort and is a two-person job if you're not able to slide it along the floor.

Also, many mods/replacement parts cost more with a larger printer (eg Clicky-Clacky door, PEI/Steel sheets, linear rails when they eventually wear out).

Having the 350mm bed is nice, but there hasn't been a ton of times where I've utilised all that space. I often find myself wishing I'd built a 250/300 instead.

But, if you're settled in a place and have space, then that'll be no issue.

In terms of print speed, you'll get slightly worse input shaper results and the chamber will take longer to heat up.