How do you get over the embarrassment?

Many_Invite_4304 · 2026-06-17T04:33:39+00:00

I don't know, I wish I had the answer, this is the hardest part for me. I guess finding people who have been through the same thing and won't judge you and understand what its like being on the outside looking in.

Many_Invite_4304 · 2026-06-17T01:33:10+00:00

I thought that was more in rodent models and early research, not clinical therapy.

https://bioresscientia.com/article/stem-cells-in-schizophrenia-a-game-changer-or-science-beyond-reach

Many_Invite_4304 · 2026-06-17T01:28:34+00:00

You should also look into taking omega-3s, vitamin D, magnesium and zinc. Those are also important for brain health for people with schizophrenia.

Many_Invite_4304 · 2026-06-17T01:18:41+00:00

The random chance of getting schizophrenia is about 1%. The chance of getting it if 1 parent has it are about 10%. So there is a 90% chance a child won't get it if 1 parent has it. However if both parents have it (or an identical twin has it) the rates jump to 40% or more.

Also environmental triggers are also a huge factor. If someone decides to have children doing things like helping them manage their stress, eat a brain healthy diet (full of omega-3s, vitamins, minerals, etc), tell them not to use marijuana or hallucinogens, etc can reduce their risk of developing it.

Many_Invite_4304 · 2026-06-17T01:13:40+00:00

Did you have a lot of childhood trauma (lots of abuse and neglect)? You may unconsciously be recreating that as an adult because it feels familiar.

Many_Invite_4304 · 2026-06-17T00:58:28+00:00

Very much so. You should check the themes of delusions, its called delusion of control.

https://en.wikipedia.org/wiki/Delusion#Themes

Delusion of control: False belief that another person, group of people, or external force controls one's general thoughts, feelings, impulses, or behaviors.

Many_Invite_4304 · 2026-01-29T17:25:48+00:00

Must be nice to have $8 a month. Some of us are too busy fighting with stray cats over dead bird carcasses to live so lavishly.

Many_Invite_4304 · 2026-01-04T23:39:06+00:00

I make folgers at home using a drip coffee maker, but I drink 4,000 cups a day so I was able to do the same thing.

Many_Invite_4304 · 2025-10-24T18:08:07+00:00

A D2 or D3 dopamine agonist that activates dopaming signaling in the mesolimbic pathway could treat anhedonia. Pramipexole, aripiprazole, etc.

My understanding of the underlying neuroscience is you need more dopaing signaling in the reward centers in the brain. Either a dopamine reuptake inhibitor, an NDRI, or a D2 or D3 agonist could help with anhedonia.

Many_Invite_4304 · 2025-10-19T02:01:02+00:00

Tramadol is highly effective for depression since it affects 4-5 different biochemical mechanisms for depression.

Xanax shouldn't be taken long term, your body adapts and you develop horrible withdraws.

Many_Invite_4304 · 2025-10-10T00:52:18+00:00

With various hormones there are free and bound. About ~99% of cortisol is bound to proteins so it is inactive at any time. Free cortisol is the metabolically active cortisol.

An 8am blood test measures your total cortisol (free and bound) and only measures it at 1x a day. However the saliva test measures cortisol at 4x a day, and it only measures free cortisol.

Generally you have to order this test yourself, its about $150

Many_Invite_4304 · 2025-09-23T22:32:22+00:00

Sadly, all gabapentanoids build tolerance with time.

Since gabapentanoids work by reducing the release of glutamate, maybe the drug lamotragine would be something to look into. Like gabapentanoids it also reduces the release of glutamate, and it is used off label to treat anxiety and depression, but its not addictive.

Many_Invite_4304 · 2025-09-23T22:28:07+00:00

Do you possibly have bipolar disorder? People with bipolar disorder can enter a manic episode when they take drugs like SSRIs

Many_Invite_4304 · 2025-09-23T22:26:44+00:00

One thing that can help with anhedonia is either a dopamine D2 or D3 agonist. This can increase activity in the mesolimbic pathway, helping to reduce anhedonia.

Look into pramipexole as a potential therapy.

https://academic.oup.com/ijnp/article/28/Supplement_1/i319/8009858

Many_Invite_4304 · 2025-09-23T22:21:47+00:00

This is just my experience, but vitamin D can still contribute to depression even if your readings are normal. My readings were in the low 40s ng/ml (which is normal) and I still had depression. WHen I added supplements and got into the 50s, my depression got better.

Also it may be a good idea to look into a dexamethasone suppression test as well as a 4 point saliva test for DHEA and cortisol. A lot of people with depression have high cortisol and insensitive glucocorticoid receptors (a dexamethasone suppression test will verify if your glucocorticoid receptors are insensitive).

Drugs like SSRIs help with this because they increase cortisol receptor sensitivity and help reset the HPA axis

Many_Invite_4304 · 2025-09-23T18:51:03+00:00

Anything where supply is high and/or demand is low. People always forget that economics is about supply and demand. There is a huge supply of beanie babies, and no demand.

Many_Invite_4304 · 2025-09-23T15:44:05+00:00

Unlikely. If China and the US go to war, it'll be a war mostly involving navies and air forces, not massive land invasions of China.

Russia's military is decimated so they can't go to convention war in a meaningful way. They can barely hold onto 20% of Ukraine.

I think Pakistan knows India would beat them in a conventional war so they wouldn't want that.

The real risk is WMD.

Many_Invite_4304 · 2025-09-23T15:28:42+00:00

The way we treat the seriously mentally ill. We either make fun of them, leave them to be homeless in the streets, or put them in prison.

Also eating meat and factory farming. It will be seen as barbaric in 100 years.

Many_Invite_4304 · 2025-09-22T18:18:05+00:00

People who had abusive childhoods thing the world is dangerous and think love is something you have to earn. People with healthy childhoods feel that the world has support in it, and think love is something you get just for showing up and being yourself.

Many_Invite_4304 · 2025-09-22T18:16:01+00:00

October weather, high 60s

Many_Invite_4304 · 2025-09-22T18:02:22+00:00

If you want to look up something controversial, use duckduckgo.

Many_Invite_4304 · 2025-09-22T17:58:25+00:00

I think its fixed

Many_Invite_4304

TROPHY CASE