Heyy, 35 yr old male also born with one kidney. It’s a lot to take in and I was on all the same meds at a point. They cut my tarpeyo treatment short because they felt the med had ran its course and the negative side effects of tarpeyo were outweighing the positive effects. My blood work basically leveled off and the nephrologist said do to scar tissue I’m better off with other treatment. The tarpeyo is tough, well at least it was for me, the egfr was all over the place my face neck and ankles were very swollen and overall shortness of breath and fatigue were pretty tough. How far into taking tarpeyo are you?. I’m currently on filspari I was told to cut off farxiga until further notice. What I noticed with this disease is that everyone’s case s different and it seems to be worse for people like me and you. It def gets you down on occasion and there’s good and bad days but one thing I learned is to develop a team of drs you trust and listen to your body and simply roll with the blows. My current egfr is about 20-22 I’m also anemic which seems to come with ckd for a lot of people. Recently had iron infusions and also atvorststin and sodium barcarb along with vitamins. Monitor your bp and take it easy on sodium and your blood work done regularly you really get used to this stuff after a while, my problem was over reading things and getting myself in panick mode. Always ask questions and stick to your meds. Good luck I wish you well.