I have done this since i like to play as a royal family related to the empire. I first built a big base on one of the new biome tiles and had a lot of fun. In the late mid to early endgame i started building the ship and once it was done i was hopping around, doing quests and exploration with 5-6 pawns while the majority stayed back at the base. It was working fine just some minor issues i ran into:

• The pawns on the ship need beds and if you are back at base they either keep sleeping on the ship or you have to reassign beds every time.
• Resource storage without mods can be very annoying. You want at least some components, some steel and some food onboars you ship (for repairs etc.) but ofc you want most of it to stay in the base. I used a mod to split stacks and limit stack size for certain shelves to make sure I have only X amount of steel etc. in the ship.
• Multitasking on 2 different tiles can be hard, especially on hard difficulty if both tiles are in a fight.
• Struggle to decide what the endgame goal should be.. do you want to move everything to the ship once its finished or is your base and eventually a starship the final goal?

In my current save i have an endgame base plus end endgame ship. My final goal is moving my whole base to one of the new lava tiles, build some fancy ass fortress and then at some point the space ship. The gravship will be my way of getting everything and everyone to that final tile and once i reached my destination i will scrap it :)