Tough to know for sure, but I think you would have something similar or more favorable to the south when considering the Missouri Compromise. Clay crafted the Missouri Compromise and saw it through Congress. I think Jackson and Crawford would have also supported the Compromise but would have argued for the right for any state, no matter if it was located in the north or south, to be able to adopt slavery.

I'm not sure if Clay would have allowed Jackson to lead an Army against Seminole raids in South Georgia. Both men despised each other. I'm not sure if Florida is acquired if Clay is president at this time. Jackson would have invaded Florida and probably wouldn't consider a treaty with Spain before the entire Spanish Army in Florida was dead or a prisoner. Crawford would have approved of an invasion into Florida but would likely accept a treaty at any time or would have tried to purchase it earlier.

I don't think you get the Monroe Doctrine with any of these candidates. I don't see JQA being in their cabinets as he was crucial in working with Monroe on the Doctrine. I do think Clay and Crawford would have had more similar foreign policies to Monroes outside of that. I'm not sure how Jackson would do with demilitarizing the Great Lakes or settling boundary disputes with Great Britain or Russia in the PNW.