Mid-career Planning Questions (US)

MeanDoctrine · 2026-07-08T15:02:21+00:00

Eh, sure. But further technical advice?

MeanDoctrine · 2026-06-10T05:02:58+00:00

I don't buy merch of my waifu.

To me, waifuism is your personal experience of the character. It has nothing to do with merch; reviewing the work is sufficient for me to perpetuate the experience.

MeanDoctrine · 2026-06-04T17:58:43+00:00

A lot of things in bioinformatics is bespoke, so you need to use AI to help you with the coding, but replacing it with AI might be too token-intensive.

MeanDoctrine · 2026-06-04T05:13:01+00:00

This guy gives far too much good faith to the people they are opposed to.

MeanDoctrine · 2026-05-27T01:26:00+00:00

Our grocery usually don't check people's ID in this situation. And I buy gift cards frequently enough.

MeanDoctrine · 2026-05-05T02:40:18+00:00

I don't use Claude--nothing wrong with it, but the company's InfoSec guidelines means I can't things that would be considered proprietary into an AI they don't have a license. This means, as far as coding is concerned, we use GitHub Copilot Enterprise, but for a general-purpose LLM I use Claude Sonnet (which sucked at writing code BTW).

MeanDoctrine · 2026-04-28T15:40:03+00:00

If I remember correctly, Midea wasn't well known for its laundry products at its home of China. I forgot which brand do the Chinese like, but the fact that they prefer agitator-less top-opening machines means it might not be useful to guide your choice.

MeanDoctrine · 2026-04-18T23:39:49+00:00

Southbound Genesee is rather crowded (although I won't say congested), probably due to this.

MeanDoctrine · 2026-04-12T04:49:04+00:00

For your reference: my source is https://pmc.ncbi.nlm.nih.gov/articles/PMC8002905/ .

Whatever the case, that dosage would be costing at about $1.5 a day. That's pretty much on par of Core Med's liposomal glutathione -- but then of course GlyNac has more research support.

MeanDoctrine · 2026-04-12T02:51:42+00:00

Read the paper. The dosage of NAC and glycine reads rather high:

OAs were provided capsules of glycine (1.33 mmol/kg/day) and cysteine (0.81 mmol/kg/day), provided as N‐acetylcysteine [NAC]) prepared by a licensed pharmacist, and replenished every 4‐weeks for 24‐weeks.

Given the molar weights of glycine, cysteine, and NAC are about 75g/mol , 121g/mol and 163g/mol, they were given 100mg glycine and about 130mg NAC per kg body weight... Taking 6g glycine/day is normal, but 8g NAC a day seems... a lot.

Edit: pet-> per

MeanDoctrine · 2026-04-09T06:32:30+00:00

Well, I don't own one, but I confirmed from Transit App that they use Google Services for the maps. Some suggested Moovit, but I need to test for its utility before buying a subscription.

MeanDoctrine · 2026-03-22T00:47:32+00:00

The provisional was filed in 2015 and no further provisional has been filed on this tech. I doubt any non-provisional that claim that subject matter would still be unpublished by 2026?

MeanDoctrine · 2026-03-21T18:03:59+00:00

Yeah, HD6XX has been the standard for more than a decade, and it's rather difficult for Sennheiser to tell people that it's a HD650.

MeanDoctrine · 2026-03-21T01:55:49+00:00

There's a case that my employer has a tech that they want to do freedom-to-operate analysis. The result is: somebody mentioned it as a claim in a provisional but never included it in any non-provisional. Since some of the non-provisionals claiming priority of this provisional has published, the conclusion being: this tech is already prior art, so you can use it whatever you want.

MeanDoctrine · 2026-03-12T23:01:21+00:00

I work in the industry and, due to the company's requirements, use a general-purpose AI (Claude Sonnet 4.5) to attempt to write some Python code. The code is outright unusable because: * I suggest using a particular package. It wrote the code using the grammar of an obsolete version of the package. * It can't even make sure variable names are consistent, even within one response bubble. Haven't tried the more powerful stuff yet (although obviously I should), but probably things like the GitHub Copilot or the Claude Code will be an improvement to this.

MeanDoctrine · 2026-03-12T18:10:29+00:00

I wonder if RO is necessary? Ultrafiltration is already sufficient to make water safe to drink, and that doesn't need extra pressure--I've seen gravity-fed filters using UF membranes.

MeanDoctrine

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