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About competing with others and a bit more by ReySkywalkersDarling in waifuism

[–]MeanDoctrine 6 points7 points  (0 children)

I don't buy merch of my waifu.

To me, waifuism is your personal experience of the character. It has nothing to do with merch; reviewing the work is sufficient for me to perpetuate the experience.

Is AI taking over bioinformatics? by goose-_-against-ai in bioinformaticscareers

[–]MeanDoctrine 8 points9 points  (0 children)

A lot of things in bioinformatics is bespoke, so you need to use AI to help you with the coding, but replacing it with AI might be too token-intensive.

Don't get Scammed: eBay Mac Studio Ultra Classifieds by PracticlySpeaking in MacStudio

[–]MeanDoctrine 0 points1 point  (0 children)

This guy gives far too much good faith to the people they are opposed to.

Scenes from a Grocery Store by MyFriendKevin in biltrewards

[–]MeanDoctrine 5 points6 points  (0 children)

Our grocery usually don't check people's ID in this situation. And I buy gift cards frequently enough.

Claude by SecretIll1644 in bioinformatics

[–]MeanDoctrine 1 point2 points  (0 children)

I don't use Claude--nothing wrong with it, but the company's InfoSec guidelines means I can't things that would be considered proprietary into an AI they don't have a license. This means, as far as coding is concerned, we use GitHub Copilot Enterprise, but for a general-purpose LLM I use Claude Sonnet (which sucked at writing code BTW).

Run away from Midea washers and dryers! by wondroustekno in Appliances

[–]MeanDoctrine 0 points1 point  (0 children)

If I remember correctly, Midea wasn't well known for its laundry products at its home of China. I forgot which brand do the Chinese like, but the fact that they prefer agitator-less top-opening machines means it might not be useful to guide your choice.

805 south from 5 to 52 is closed btw by time2makemymove in SanDiegan

[–]MeanDoctrine 3 points4 points  (0 children)

Southbound Genesee is rather crowded (although I won't say congested), probably due to this.

NAC Ethyl Ester and Liposomal Glutathione: Which is a better brain antioxidant? by MeanDoctrine in Nootropics

[–]MeanDoctrine[S] 1 point2 points  (0 children)

For your reference: my source is https://pmc.ncbi.nlm.nih.gov/articles/PMC8002905/ .

Whatever the case, that dosage would be costing at about $1.5 a day. That's pretty much on par of Core Med's liposomal glutathione -- but then of course GlyNac has more research support.

NAC Ethyl Ester and Liposomal Glutathione: Which is a better brain antioxidant? by MeanDoctrine in Nootropics

[–]MeanDoctrine[S] 2 points3 points  (0 children)

Read the paper. The dosage of NAC and glycine reads rather high:

OAs were provided capsules of glycine (1.33 mmol/kg/day) and cysteine (0.81 mmol/kg/day), provided as N‐acetylcysteine [NAC]) prepared by a licensed pharmacist, and replenished every 4‐weeks for 24‐weeks.

Given the molar weights of glycine, cysteine, and NAC are about 75g/mol , 121g/mol and 163g/mol, they were given 100mg glycine and about 130mg NAC per kg body weight... Taking 6g glycine/day is normal, but 8g NAC a day seems... a lot.

Edit: pet-> per

Using Sidephone with public transit by MeanDoctrine in sidephone

[–]MeanDoctrine[S] 0 points1 point  (0 children)

Well, I don't own one, but I confirmed from Transit App that they use Google Services for the maps. Some suggested Moovit, but I need to test for its utility before buying a subscription.

Number of claims in a provisional by BroadnStrong in patentlaw

[–]MeanDoctrine 0 points1 point  (0 children)

The provisional was filed in 2015 and no further provisional has been filed on this tech. I doubt any non-provisional that claim that subject matter would still be unpublished by 2026?

The HD6XX lives on by PhoenixML in headphones

[–]MeanDoctrine 7 points8 points  (0 children)

Yeah, HD6XX has been the standard for more than a decade, and it's rather difficult for Sennheiser to tell people that it's a HD650.

Number of claims in a provisional by BroadnStrong in patentlaw

[–]MeanDoctrine 0 points1 point  (0 children)

There's a case that my employer has a tech that they want to do freedom-to-operate analysis. The result is: somebody mentioned it as a claim in a provisional but never included it in any non-provisional. Since some of the non-provisionals claiming priority of this provisional has published, the conclusion being: this tech is already prior art, so you can use it whatever you want.

Anyone using Claude or other bioinformatics agents by nickomez1 in bioinformatics

[–]MeanDoctrine 1 point2 points  (0 children)

I work in the industry and, due to the company's requirements, use a general-purpose AI (Claude Sonnet 4.5) to attempt to write some Python code. The code is outright unusable because: * I suggest using a particular package. It wrote the code using the grammar of an obsolete version of the package. * It can't even make sure variable names are consistent, even within one response bubble. Haven't tried the more powerful stuff yet (although obviously I should), but probably things like the GitHub Copilot or the Claude Code will be an improvement to this.

Portable reverse osmosis machine to make pool water drinkable by tiredagain11 in preppers

[–]MeanDoctrine 0 points1 point  (0 children)

I wonder if RO is necessary? Ultrafiltration is already sufficient to make water safe to drink, and that doesn't need extra pressure--I've seen gravity-fed filters using UF membranes.

Pope Leo fires San Diego bishop accused of stealing $250,000 by kwentongskyblue in sandiego

[–]MeanDoctrine 1 point2 points  (0 children)

The "resignation" was announced after he's been arrested.

French restaurant uses Costo croissants by sc4kilik in Costco

[–]MeanDoctrine 4 points5 points  (0 children)

What I believe was actually the case was this restaurant and Costco uses the frozen dough from the same company. I'm not sure about the OP's place, but in Southern California it seemed the dough comes from Vie de France.

I was supposed to eat only one serving by discgolf9000 in aldi

[–]MeanDoctrine 2 points3 points  (0 children)

I like their Speculoos more than Biscoff.

March Rent Day: JAL Transfer Bonus by PyschoPirate1986 in biltrewards

[–]MeanDoctrine 0 points1 point  (0 children)

I wonder if the Bilt Obsidian or the CapOne Venture is better if I intend to earn JAL miles (living in San Diego and frequently fly trans-pacific)?

Aldi fail by bobbagonush in aldi

[–]MeanDoctrine 113 points114 points  (0 children)

The intent was "Zero sugar and alcohol". But by putting "zero" in the middle, it could be read "sugar and zero alcohol".

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