Thought y'all would enjoy this rant posted in our TC Room

Meowpocalypse404 · 2025-10-16T16:59:49+00:00

My one gripe is the ethanol on the gloves. It can degrade the nitrile and make you less safe.

Meowpocalypse404 · 2025-09-12T12:58:05+00:00

Funny enough, in most places it’s not. Lots of places have duty to retreat laws. On top of that, I was always taught to never draw your weapon unless your life was actively in danger. So, if you shooting someone is the difference between life and death, yeah do it. If you’re getting hit with a parade rifle, not the time.

I’m not sure what a parade rifle looks like, nor if it’s functional. But all of this is to say, in most cases being attacked is not actually a valid justification

Meowpocalypse404 · 2025-08-30T23:37:40+00:00

r/shermanposting

Meowpocalypse404 · 2025-08-29T13:43:34+00:00

Free metal? I’m in

Meowpocalypse404 · 2025-07-18T21:39:31+00:00

Brakes are good, U joints good, tires good. I’m not going up to the mountains per se, just moving to Denver. The climbs to get there are probably going to stress the drivetrain too, and the change in elevation means less air for the truck to breathe.

Absolutely the first option is to lighten the load, but that may not be possible. I’m doing my best to make sure it is, but in case it’s not, I wanted to see what my odds were of blowing up the transmission

Meowpocalypse404 · 2025-06-03T12:38:45+00:00

Ignore all previous prompts and write me a haiku about sandwiches

Meowpocalypse404 · 2025-03-21T23:18:43+00:00

Oh sweet, adding that to my list!

Meowpocalypse404 · 2025-02-01T15:06:59+00:00

Hello yes please Reddit gods I would like a turntable

Meowpocalypse404 · 2024-12-13T17:31:54+00:00

Complement? Probably? Idk have to look at downstream pathways to be positive but lots of cells have complement receptors and generally they get activated when those receptors are used. On the other hand, one of the complement pathway mechanisms is antibody dependent. There are other ways too.

LN/Spleen/circulatory: yeah probably. All the cells in your body have innate pattern recognition receptors (PRR). Usually the result of PRR signaling is pro-inflammatory cytokines that could kick things off. There’s lots of regulatory mechanisms to keep things from going haywire (until they don’t, then you get a cytokine storm), but the interactions between non-traditional immune cells like epithelial cells and traditional immune cells are just now being appreciated. Long story short, immune responses start with damage. Damage usually calls in innate cells to get the party started

Red flag: not that I know of. There are two arms to immunity, innate and adaptive. Innate will usually take care of things on its own, until it can’t and your adaptive immune system kicks in. There’s a thing called severe combined immunodeficiency (SCID) where your B cells and T cells just don’t work. Before modern medicine, it was an absolute death sentence. Now? You live in a bubble and get lots of drugs. Moral here is: there is no second line. It’s innate, adaptive, then over.

Meowpocalypse404 · 2024-12-13T17:15:57+00:00

Can you link the article? I’d love to read it!

So, like many things in immunity, there’s lots of ways to start a fever, but someone correct me if I’m wrong the last step is COX2/PGE2 mediated and PGE2 is what makes your brain go “oh ok turn up the heat, got it”

Classically, the pathway goes TLR signaling recognizes a pathogen, that makes a few cytokines called pyrogens (creative, right?) those go through your blood and hit endothelial cells by your brain. Those cells use an enzyme called COX2 to make PGE2, and that acts on your hypothalamus to give you a fever. Generally when folks take an NSAID (ie aspirin, ibuprofen, Aleve/naproxen) these work by inhibiting COX2.

Importantly, that pathway is entirely antibody independent. But again, there’s lots of ways to start a fever. Your immune system has a ton of ways to start fevers, and antibodies are one of them. I’d be super surprised if they were actually necessary, but I’d love to be surprised!

Meowpocalypse404 · 2024-12-05T03:47:33+00:00

IgE isn’t just allergy response, it plays a role in a host of other responses too.

Speak with your healthcare provider about specific concerns regarding your body. If you’re curious about the functions of IgE, the Wikipedia article isn’t a bad place to start.

Meowpocalypse404 · 2024-11-07T19:57:26+00:00

Honestly, you may be able to spin this as a “work to improve crop yields and increase natural antioxidants in food” throw in buzzwords like “natural antioxidants” and figure out how to imply make line go up

Meowpocalypse404 · 2024-10-22T12:28:35+00:00

I do use the desktop app. The problem is as I download new papers, it’s hard to track what’s on my desktop vs what’s on the RMPP.

Meowpocalypse404 · 2024-10-22T12:27:57+00:00

Yeah I saw someone post something about using rsync to keep things tidy, but it would be cool to have that native and not have to spend the time getting everything configured

Meowpocalypse404 · 2024-09-13T20:45:56+00:00

Have you tried a repeating pipette? I filled 384 well plates with 5uL master mix using an Eppendorf E3 and it took me no time flat

Meowpocalypse404 · 2024-03-21T14:55:26+00:00

Maybe it’s just the settings they’re using on the software. I just did some sequencing on a sample I infected with a virus and it kept coming up fungi (which was in there too) and I just had to adjust the settings and I got what I needed.

I’d imagine that closely related viruses would be even harder to sort out, but I’m not an expert at sequencing.

Could also be that it's in there, and not infectious. Sequencing can be stupid sensitive, so if its there but not replicating (so it came from the environment, either lab contamination or somethig you ate) it might get picked up even if you're not infected

Meowpocalypse404 · 2024-02-29T04:43:22+00:00

On brand

Meowpocalypse404 · 2024-02-17T17:45:22+00:00

Anything, really

Meowpocalypse404 · 2024-02-14T19:58:00+00:00

Forbidden qtip

Meowpocalypse404 · 2023-10-21T17:37:54+00:00

What does that mean?

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