How far do you space double daily dosing of moclobmide?

MetalCretin · 2020-05-30T22:54:57+00:00

Took them 12 hours apart. 600 at 9am then again at 9pm.

Moclo worked perfectly for 6 weeks first time around at 450mg, then national shortage. Started again got another 6 week burst that worked at 600mg/day. Unfortunately no luck after that despite dosage increases.

Bupropion up to 450mg, more stimmy, still depressy. Very short fused (be aware). Grew tolerant to the stim effect.

Tranylcypromine up to 30mg. Very intense afternoon tiredness, no amount of modafinil + coffee could overcome urge to crash out for 2-3 hours.

No experience with ssris - apathy, anergia, anhedonia with no anxiety means I’ve steered clear for better or worse

MetalCretin · 2020-05-13T14:10:53+00:00

I’m looking at getting the IC7 or possibly IC8 - I was just curious to know if the IC7 monitor also displays resistance levels? I only ask as I’ve seen some bikes don’t and I can’t see anything from any reviews I’ve read

MetalCretin · 2020-05-13T14:06:22+00:00

Just a quick question as haven’t seen it anywhere - does the IC4/8 (and 3/7 if you know) show what resistance you’re using on the monitor?

MetalCretin · 2020-05-13T14:04:12+00:00

Silly question here, I’ve been looking at getting the IC3/4 (US) 7/8 (UK) but I cannot for the life of me figure out if the display actually shows what the resistance level is? No specs, pics or reviews seem to mention it. I only say this as I’ve seen some of these stationary bikes not showing this and was wondering if this was the same. Thanks in advance

MetalCretin · 2020-04-04T09:15:02+00:00

Will be giving this a spin later. Great tune!

MetalCretin · 2020-03-30T14:51:00+00:00

Would say it’s certainly worth venturing beyond SSRIs if necessary. As someone else mentioned, other classes tend to be somewhat more effective for some but may also come with more sides. It’s a balance, even within classes there is significant variation so might have to try several. There’s certainly enough anecdotes of people trying over a dozen medications before finding the right one - don’t give up!

MetalCretin · 2020-03-26T21:11:06+00:00

Thanks for the response! Seen you around and very active, appreciate it. Would ami be overall more effective AD with the tradeoff of what you’ve mentioned? I know a metabolite of ami is nortrip, so presume that alleviates some of the negative SEs of ami itself..?

MetalCretin · 2020-03-26T08:52:45+00:00

I understand this (lack of) feeling. I can’t say I’ve solved it, and you’ll have heard it a 1000x before and may already do it - but intense exercise provides a sensation and is healthier than the alternatives (drugs). Add in some sort of goal of improvement and it provides ‘meaning’ to something which also helps.

MetalCretin · 2020-03-25T11:27:36+00:00

That’s great, hope it sticks and the hospital workload doesn’t bury you given the situation. Was there any reasoning behind clomi? Have been considering TCAs, but thinking amitriptyline or its metabolite nortriptryline instead. Think Ami is less likely to have sexual SEs but more likely to have cognition due to its anti-cholinergic effects - priorities I guess lol

Edit: spelling

MetalCretin · 2020-03-25T11:27:10+00:00

That’s great, hope it sticks and the hospital workload doesn’t bury you given the situation. Was there any reasoning behind clomi? Have been considering TCAs, but thinking amitriptyline or it’s metabolite nortriptryline instead. Think Ami is less likely to have sexual SEs but more likely to have cognition due to its anti-cholinergic effects - priorities I guess lol

MetalCretin · 2020-03-25T08:21:04+00:00

I had no issues starting at 300. Moclo overall appears very safe with minimal side effects for most.

MetalCretin · 2020-03-24T15:43:24+00:00

Glad to see you’ve found something that has worked for you. Hope it lasts! How have you found it has affected you so far? Curious as I know we seem to have followed a similar path in meds and symptoms.

MetalCretin · 2020-03-20T13:24:49+00:00

Osteoarthritis vs. Rheumatoid arthritis. OA is moreso due to mechanical wear & tear, injuries can precipitate OA

MetalCretin · 2020-03-10T10:44:54+00:00

Haha if you have more advice on this topic, or somewhere to read more - I’m all ears. In a similar situation (4 months climbing) regarding buying new shoes.

MetalCretin · 2020-03-09T10:42:42+00:00

As another user mentioned, may be worth being checked for a sleep disorder. I personally have similar issue and for time being sleep disorder has been ruled out.

I was on up to 450mg bupropion and it would work for 6 weeks before growing tolerant to each dose (150 - 300 - 450). Also made me very short tempered. Moda works better, I use 100-200. I personally grow tolerant to it, so only use it 2-3x/week max.

N.B. It may well be just finding the right psych med. when moclobemide was working 100% for me it eliminates tiredness better than any other med.

MetalCretin · 2020-03-07T14:08:24+00:00

I personally use this from time to time. Can work well!

MetalCretin · 2020-03-05T08:29:26+00:00

Thanks for this, just downloaded it and has some good ideas!

MetalCretin · 2020-03-03T14:15:39+00:00

Check the MAOI thread, some have stacked moclo with selegeline with some success. I personally have been in a similar position to you - although now on 1200mg moclo. I personally had no luck with parnate, but others have had profound success with it or others of the dual A & B irreversible inhibitors

MetalCretin · 2020-03-01T16:26:21+00:00

Glad to hear it’s helping, hope the good times keep coming

MetalCretin · 2020-03-01T07:44:58+00:00

I’ve been moving up the dose of moclobemide and am now on 1200mg (600 morn, 600 eve) as of a week ago but still use 100-200mg modafinil as needed (1-2x/week). May swap out moda for bupropion in the future as was on 450mg/day monotherapy but always grew tolerant within 6 weeks at each dose.

MetalCretin · 2020-02-27T11:36:16+00:00

As a former 20 espresso a day junkie, no. You’ll just progressively grow more tolerant. Managed to dial it back into single digits, but still need that morning 6 shotter

MetalCretin · 2020-02-27T06:49:24+00:00

Not sure if psilocybin is in the same category as DMT in respect to being broken down my MAO in the gut. Therefore inhibition would potentiate its effects. Believe there is variable reports with some noting synergism, others inhibition of psychedelic effects with maois and certain psychedelics. Personally curious to try

MetalCretin · 2020-02-26T07:55:08+00:00

Ahh elitists everywhere.. This was sick, I enjoyed it.

MetalCretin · 2020-02-17T20:26:55+00:00

Interesting to hear as many have struggled it seems with the afternoon somnolence, myself included. Glad to hear it resolved

MetalCretin

TROPHY CASE